| Project/Area Number |
25650044
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
LI Chun-Biu 北海道大学, 電子科学研究所, 准教授 (90397795)
KAWAI Shinnosuke 北海道大学, 電子科学研究所, 特任助教 (90624065)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 分子個性 / 情報理論 / F1-ATPase / ネットワーク / 1分子計測 / 変化点解析 / 反応ネットワーク / 経路の多重性 / ノイズ除去 / 遷移状態 / 自由エネルギー地形 / 一分子計測 / 非平衡定常状態反応ネットワーク / システム生物学 |
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| Outline of Final Research Achievements |
From single molecule finite time series that changes discretely such as opened or closed, (substrate) bound or unbound, we developed a novel analysis method that objectively elucidates the state of molecules in terms of network representation and enables us to predict the future output of the molecular data in time. In addition, by developing a novel data analysis method that does not assume a form of function of likelihood, we revealed the molecular mechanism of efficient energy conversion in F1-ATPase that synthesizes “energy money”inside cell, ATP, and ATP hydrolysis designs the order of reactions.
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