| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Membrane proteins embedded in cell membranes play various important roles in the cellular functions. In this study, we have developed stable lipid bilayer nanodiscs, which can be applied to a functional and structural analysis of membrane proteins. The membrane-active amphiphiles designed in this study spontaneously formed nanodiscs through the interaction with a hydrophobic edge of a lipid bilayer. It was demonstrated that obtained nanodisc has a potential as a novel matrix for the membrane protein reconstitution.
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