Development of novel platforms for membrane protein analysis
| Project/Area Number |
25650053
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
YASUHARA Kazuma 奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (90545716)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 膜タンパク質 / 脂質二分子膜 / バイセル / 自己組織化 / 有機-無機ハイブリッド |
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| Outline of Final Research Achievements |
Membrane proteins embedded in cell membranes play various important roles in the cellular functions. In this study, we have developed stable lipid bilayer nanodiscs, which can be applied to a functional and structural analysis of membrane proteins. The membrane-active amphiphiles designed in this study spontaneously formed nanodiscs through the interaction with a hydrophobic edge of a lipid bilayer. It was demonstrated that obtained nanodisc has a potential as a novel matrix for the membrane protein reconstitution.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article]2014
Author(s)
S. Junedi, K. Yasuhara, S. Nagao, J. Kikuchi, S. Hirota
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Journal Title
ChemBioChem
Volume: Vol. 15, No. 4
Issue: 4
Pages: 517-521
DOI
Related Report
Peer Reviewed
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