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Regulation of interaction between cells and microenvironment by metabolic cooperation

Research Project

Project/Area Number 25650060
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cell biology
Research InstitutionHokkaido University

Principal Investigator

Onodera Yasuhito  北海道大学, 医学(系)研究科(研究院), 講師 (90435561)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords代謝 / 細胞間相互作用 / 微小環境 / シグナル / 共培養 / 組織培養 / 糖代謝 / 小胞輸送
Outline of Final Research Achievements

We have previously reported that regulation of glucose metabolism is tightly connected to that of signaling cascades, which is fundamental for the establishment and maintenance of tissue architecture. In order to examine whether and how metabolic cooperation between different types of cells regulates the cell-cell and cell-microenvironment interaction and orchestrates cell behaviors, we have investigated new techniques to obtain double-layered structure made of different types of cells, which resembles acinar and tubular structures of mammary gland. We have also established a novel method to incorporate stable isotope-labeled glucose (e.g. 13C glucose) into only specific cells, which enables us to examine and manipulate metabolic cooperation between different types of cells in the microenvironment. Using these methods, the metabolic cooperation between luminal epithelial and myoepithelial cells of mammary gland is now investigated.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results) (of which Invited: 2 results)

  • [Journal Article] 転写後調節と代謝2016

    • Author(s)
      小野寺康仁
    • Journal Title

      生化学

      Volume: 88-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways.2014

    • Author(s)
      Onodera Y, Nam JM, Bissell MJ
    • Journal Title

      The Journal of Clinical Investigation

      Volume: 124 Issue: 1 Pages: 367-384

    • DOI

      10.1172/jci63146

    • NAID

      120005372327

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intracellular trafficking of integrins in cancer cells.2013

    • Author(s)
      Onodera Y, Nam JM, Sabe H.
    • Journal Title

      Pharmacol Ther.

      Volume: 140 Issue: 1 Pages: 1-9

    • DOI

      10.1016/j.pharmthera.2013.05.007

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 糖代謝と小胞輸送の相互作用を介したがん形質の誘導2015

    • Author(s)
      小野寺康仁
    • Organizer
      がんと代謝研究会
    • Place of Presentation
      石川県立音楽堂(石川県金沢市)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Increased glucose metabolism activates oncogenic pathways in breast cancer.2014

    • Author(s)
      Onodera Y, Nam JM, Bissell MJ
    • Organizer
      1st GI-CORE   Medical Science and Engineering Symposium
    • Place of Presentation
      札幌パークホテル(北海道)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 乳癌における「解糖系シグナル」の役割とメカニズム2013

    • Author(s)
      小野寺康仁,南ジンミン,Mina Bissell
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] 乳癌における「糖代謝シグナル」の役割2013

    • Author(s)
      小野寺康仁,南ジンミン,Mina Bissell
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] 糖代謝シグナルによるがん形質の誘導2013

    • Author(s)
      小野寺康仁,南ジンミン,Mina Bissell
    • Organizer
      第1回がんと代謝研究会
    • Place of Presentation
      鶴岡市先端研究産業支援センター(鶴岡)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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