| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
The endoplasmic reticulum (ER) stress transducer BBF2H7 is an ER-resident transmembrane protein. In response to ER stress, it is processed at the transmembrane region to generate a cytoplasmic N-terminus and luminal c-terminus. We found that BBF2H7 C-terminus is secreted into extracellular space as a signaling molecule for cell-to-cell communication. The secreted BBF2H7 c-terminus directly binds to both hedgehog and its receptor Patched-1, followed by activation of hedgehog signaling, resulting in promoting the proliferation of neighboring cells. The effects of BBF2H7 C-terminus on cell growth are observed in developing chondrocytes and tumor cells such as glioblastomas and breast cancers.
|
