The molecular mechanisms of cell-to-cell communication by a cleaved endoplasmic reticulum stress transducer
| Project/Area Number |
25650069
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞内情報伝達機構 / 小胞体 / ヘッジホッグシグナル / 細胞増殖 / 軟骨 / 癌 |
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| Outline of Final Research Achievements |
The endoplasmic reticulum (ER) stress transducer BBF2H7 is an ER-resident transmembrane protein. In response to ER stress, it is processed at the transmembrane region to generate a cytoplasmic N-terminus and luminal c-terminus. We found that BBF2H7 C-terminus is secreted into extracellular space as a signaling molecule for cell-to-cell communication. The secreted BBF2H7 c-terminus directly binds to both hedgehog and its receptor Patched-1, followed by activation of hedgehog signaling, resulting in promoting the proliferation of neighboring cells. The effects of BBF2H7 C-terminus on cell growth are observed in developing chondrocytes and tumor cells such as glioblastomas and breast cancers.
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Report
(3 results)
Research Products
(53 results)
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[Journal Article] Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation of the ER Stress Transducer BBF2H7/CREB3L2 in Chondrocytes.2014
Author(s)
Hino K, Saito A, Kido M, Kanemoto S, Asada R, Takai T, Cui M, Cui X, Imaizumi K.
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Journal Title
Journal of Biological Chemistry
Volume: 289
Issue: 20
Pages: 13810-13820
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells.2013
Author(s)
Miyagi H, Kanemoto S, Saito A, Asada R, Iwamoto H, Izumi S, Kido M, Gomi F, Nishida K, Kiuchi Y, Imaizumi K.
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Journal Title
PLOS ONE
Volume: 8
Issue: 1
Pages: 55155-55155
DOI
Related Report
Peer Reviewed
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