Grant-in-Aid for Challenging Exploratory Research
Secretory proteins are synthesized and folded with endoplasmic reticulum (ER) chaperones in the ER, and received various post-translational modifications such as glycosylation. The ER and Golgi stress responses are the mechanisms that augment function of each organelle in accordance with cellular demands. In this project, we planned to reveal the mammalian molecular mechanisms of the ER and Golgi stress responses through the structural analyses of pATF6(P), pXBP1(U) and TFE3, key regulators of the ER and Golgi stress response. Finaly, we obtained pXBP1(U) protein for the analysis of X-ray crystallography.
Cell Struct. Funct.
Current Opinion in Nephrology and Hypertension
Volume: in press
Volume: Vol. 38
Comput Struct Biotechnol J.
Attribution of KAKENHI