| Project/Area Number |
25650084
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Waseda University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 細胞競合 / エネルギー代謝 / Myc / p53 |
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| Outline of Final Research Achievements |
Our studies have revealed that developing wing cells in Drosophila melanogaster that differ in expression levels of Drosophila c-Myc (dMyc) can compete, leading to the apoptosis of the cells with less dMyc (“losers”) and over-representation of cells with more dMyc (“winners”) in the wing. This phenomenon, called cell competition, seems to play a crucial role in the control of organ size.
We find that expression of dMyc induces metabolic reprogramming resembling the Warburg effect, which is balanced by homeostatic metabolic functions of p53. However, in mosaics, confrontation between dMyc-expressing and wildtype cells heightens the metabolism of dMyc cells and leads p53-dependency for their clonal expansion, viability, and super-competitor status. We propose that confrontation with WT cells increases the fitness of dMyc cells and that p53 functions as a sensor of these fitness differences.
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