Analysis of the space-occupying process as a novel phenomenon in cell adhesion

• Project/Area Number: 25650109
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Morphology/Structure
• Research Institution: Sapporo Medical University
• Principal Investigator: KOHNO Takayuki 札幌医科大学, 医学部, 講師 (10374563)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 場所取り / 細胞接着

Outline of Final Research Achievements

Cell adhesion onto a cell culture plate is a necessary for a normal cell growth in every monolayer adherent cells. Once adherent cells were suspended, it is known that many extracellular matrix components were released from cells to create an anchor for the cell culture plate. In this study, I discovered a novel event of an exclusive reservation for cell adherent area, which we named “space-occupying process” in cell adhesion processes. Moreover, I tried to identify the factor in this phenomenon.