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Roles of novel GnRH neurons in the hindbrain, spinal cord, and retina

Research Project

Project/Area Number 25650118
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Animal physiology/Animal behavior
Research InstitutionKonan University

Principal Investigator

KUSAKABE Takehiro  甲南大学, 理工学部, 教授 (40280862)

Co-Investigator(Renkei-kenkyūsha) KUHARA Atsushi  甲南大学, 理工学部, 准教授 (00402412)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsGnRH / メダカ / ホヤ / 中枢神経系 / プラコード / 網膜
Outline of Final Research Achievements

Gonadotropin-releasing hormone (GnRH) is a neuroendocrine peptide that plays a central role in the control of vertebrate reproductive functions. Three major GnRH systems have been characterized in vertebrates: the conventional hypophysiotropic GnRH system and two extrahypothalamic GnRH systems. Whether hypophysiotropic or extrahypothalamic, most functions of the GnRH systems have been implicated in the control of reproductive activities. The tunicate Ciona intestinalis has in its non-reproductive larval stage a prominent GnRH system spanning the entire length of the nervous system. We have found evidence for localization of cells producing GnRH in the hindbrain, spinal cord, and retina of vertebrates, suggesting that GnRH also plays a non-reproductive role in vertebrates. Our results demonstrate that the GnRH system is deeply associated with the chordate-specific characteristics and suggest a non-reproductive role of GnRH both in tunicates and vertebrates.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (2 results) Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (9 results) (of which Invited: 2 results)

  • [Int'l Joint Research] カリフォルニア大学バークレー校(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] パリ第6大学(フランス)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 太古に遡る嗅覚と生殖のつながり ―ホヤを使った研究から―2016

    • Author(s)
      島井光太郎、日下部岳広
    • Journal Title

      AROMA RESEARCH

      Volume: 17 Pages: 42-44

    • Related Report
      2015 Annual Research Report
  • [Journal Article] The pre-vertebrate origins of neurogenic placodes2015

    • Author(s)
      Abitua, P. B., Gainous, T. B., Kaczmarczyk, A. N., Winchell, C. J., Hudson, C., Kamata, K., Nakagawa, M., Tsuda, M., Kusakabe, T. G., and Levine, M.
    • Journal Title

      Nature

      Volume: 524 Issue: 7566 Pages: 462-465

    • DOI

      10.1038/nature14657

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nonreproductive role of gonadotropin-releasing hormone in the control of ascidian metamorphosis.2014

    • Author(s)
      Kamiya C, Ohta N, Ogura Y, Yoshida K, Horie T, Kusakabe TG, Satake H, Sasakura Y.
    • Journal Title

      Developmental Dynamics

      Volume: 243 Issue: 12 Pages: 1524-1535

    • DOI

      10.1002/dvdy.24176

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcriptional co-regulation of evolutionarily conserved microRNA/cone opsin gene pairs: implications for photoreceptor subtype specification.2014

    • Author(s)
      Yutaka Daido, Sakurako Hamanishi, Takehiro G. Kusakabe
    • Journal Title

      Developmental Biology

      Volume: 392 Issue: 1 Pages: 117-129

    • DOI

      10.1016/j.ydbio.2014.04.021

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] オプシンがメダカ視細胞の形態多様性に及ぼす影響の解析2014

    • Author(s)
      細川恵梨華、赤澤菜摘、柏木洋貴、大道裕、久原篤、本多大輔、日下部岳広
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] メダカ視細胞の形態多様性を生み出す要因の検討2014

    • Author(s)
      細川恵梨華、赤澤菜摘、柏木洋貴、大道裕、久原篤、本多大輔、日下部岳広
    • Organizer
      日本動物学会第85回大会
    • Place of Presentation
      東北大学川内キャンパス(宮城県仙台市)
    • Year and Date
      2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Ciona and medaka as model organisms for studying neural development and function2014

    • Author(s)
      Take Kusakabe
    • Organizer
      Seminar at Department of Molecular & Cell Biology, University of California, Berkeley
    • Place of Presentation
      バークレー(米国カリフォルニア州)
    • Year and Date
      2014-08-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Structural and physiological analysis for a central pattern generator controlling swimming locomotion of the ascidian larva2014

    • Author(s)
      Takeo Horie, Masamichi Ohkura, Takehiro G. Kusakabe, Junichi Nakai, Masashi Nakagawa
    • Organizer
      第91回日本生理学会大会 シンポジウム「無脊椎動物から哺乳類へとつながる運動制御の神経回路 -Central Pattern Generator研究の最前線-」
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Cone subtype-specific microRNAs as putative regulators for photoreceptor subtypes: evidence from primary transcripts localization and target prediction in medaka2013

    • Author(s)
      Yutaka Daido, Takehiro G. Kusakabe
    • Organizer
      19th Japanese Medaka and Zebrafish Meeting
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] Shared cis-regulatory modules regulate transcription of evolutionarily conserved and bidirectionally transcribed miRNA-opsin gene pairs in the medaka retina2013

    • Author(s)
      Yutaka Daido, Takehiro G. Kusakabe
    • Organizer
      17th International Congress of Developmental Biology
    • Place of Presentation
      Cancun, Mexico
    • Related Report
      2013 Research-status Report
  • [Presentation] Functional and structural evidence for a central pattern generator controlling swimming locomotion of the Ciona intestinalis larva2013

    • Author(s)
      Takehiro G. Kusakabe, Koki Nishitsuji, Daisuke Moriguchi, Hiroki Kashiwagi, Kotaro Shimai, Daiske Honda, Masashi Nakagawa, Masamichi Ohkura, Junichi Nakai, Yasunori Sasakura, Takeo Horie
    • Organizer
      7th International Tunicate Meeting
    • Place of Presentation
      Naples, Italy
    • Related Report
      2013 Research-status Report
  • [Presentation] 錐体オプシン遺伝子と共発現するマイクロRNAの役割2013

    • Author(s)
      大道裕、日下部岳広
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] Development and function of the sensory and motor systems in the simple chordate Ciona intestinalis2013

    • Author(s)
      Take Kusakabe
    • Organizer
      OIST Winter Course “Evolution of Complex Systems”
    • Place of Presentation
      Onna, Okinawa, Japan
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2022-01-27  

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