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Rapid karyotypic changes in a primate taxon: possibility of participation of repetitive DNA as chromosome breakage inducer

Research Project

Project/Area Number 25650152
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Physical anthropology
Research InstitutionKyoto University

Principal Investigator

KOGA Akihiko  京都大学, 霊長類研究所, 教授 (80192574)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords染色体 / 反復配列 / ゲノム / 霊長類 / 増幅 / セントロメア / ヘテロクロマチン / 進化
Outline of Final Research Achievements

The owl monkey, also called the night monkey, is a New World monkey species. This monkey exhibits rapid changes in the structure and conformation of chromosomes. The author hypothesized that the rapid changes are associated with the presence of a large amount of repetitive DNA in the owl monkey genome. This hypothesis involves, as its initial part, that the repetitive DNA that is specific to the owl monkey is fragile; easily degraded in the process of DNA replication. Experimental results indicated that this DNA is fragile and, thus, the condition necessary for the above hypothesis was fulfilled.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (5 results) (of which Invited: 1 results)

  • [Journal Article] Higher-order repeat structure in alpha satellite DNA occurs in New World monkeys and is not confined to hominoids2015

    • Author(s)
      Sujiwattanarat P, Thapana W, Srikulnath K, Hirai Y, Hirai H, *Koga A
    • Journal Title

      Scientific Reports

      Volume: 未定

    • NAID

      120005758209

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reduction in the structural instability of cloned eukaryotic tandem-repeat DNA by low-temperature culturing of host bacteria2014

    • Author(s)
      Watcharaporn Thapana, Penporn Sujiwattanarat, Kornsorn Srikulnath, Hirohisa Hirai, and Akihiko Koga
    • Journal Title

      Genetics Research

      Volume: 96

    • DOI

      10.1017/s0016672314000172

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Locational diversity of alpha satellite DNA and intergeneric hybridization aspects in the Nomascus and Hylobates genera of small apes2014

    • Author(s)
      Baicharoen S, Miyabe-Nishiwaki T, Arsaithamkul V, Hirai Y, Duangsa-ard K, Siriaroonrat B, Domae H, Srikulnath K, Koga A, *Hirai H
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 10 Pages: e109151-e109151

    • DOI

      10.1371/journal.pone.0109151

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterochromatin blocks constituting the entire short arms of acrocentric chromosomes of Azara's owl monkey : formation processes inferred from chromosomal locations2013

    • Author(s)
      Prakhongcheep O, Chaiprasertsri N, Terada S, Hirai Y, Srikulnath K, Hirai H, Koga A
    • Journal Title

      DNA Research

      Volume: 20 Issue: 5 Pages: 461-470

    • DOI

      10.1093/dnares/dst023

    • NAID

      120005343928

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] DNA-based transposable elements as natural mutators in vertebrate genomes2014

    • Author(s)
      Akihiko Koga
    • Organizer
      2014 International Conference of the Korean Society for Molecular and Cellular Biology
    • Place of Presentation
      COEX (Seoul, Korea)
    • Year and Date
      2014-10-21 – 2014-10-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Higher-order repeat structure in centromeric repetitive DNA is not confined to central regions2014

    • Author(s)
      Penporn Sujiwattanarat, Watcharaporn Thapana, Kornsorn Srikulnath, 平井啓久, 古賀章彦
    • Organizer
      日本進化学会第16回大阪大会
    • Place of Presentation
      高槻現代劇場(大阪府高槻市)
    • Year and Date
      2014-08-21 – 2014-08-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヨザルの染色体変異に関与したと考えられる大規模反復配列2014

    • Author(s)
      古賀章彦, Ornjira Prakhongcheep, Nampech Chaiprasertsri, 平井百合子, 平井啓久
    • Organizer
      第30回日本霊長類学会大会
    • Place of Presentation
      大阪科学技術センター(大阪市)
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヨザルのセントロメアを構成する反復配列の急速な置換2013

    • Author(s)
      古賀章彦、オーン・プラコンチ、コンソン・シクルナト、平井百合子、平井啓久
    • Organizer
      第29回日本霊長類学会・日本哺乳類学会2013年度合同大会
    • Place of Presentation
      岡山理科大学(岡山市)
    • Related Report
      2013 Research-status Report
  • [Presentation] ヨザルのアクロセントリック染色体短腕にあるヘテロクロマチンの形成過程2013

    • Author(s)
      平井啓久、オーン・プラコンチ、ナンペ・チャイパセルチ、平井百合子、古賀章彦
    • Organizer
      第29回日本霊長類学会・日本哺乳類学会2013年度合同大会
    • Place of Presentation
      岡山理科大学(岡山市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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