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A pilot study for elucidating molecular mechanisms regulating sexual dimorphism and diversity of human and non-human primates

Research Project

Project/Area Number 25650154
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Physical anthropology
Research InstitutionKitasato University

Principal Investigator

OOTA Hiroki  北里大学, 医学部, 准教授 (40401228)

Co-Investigator(Kenkyū-buntansha) FURUICHI Takeshi  京都大学, 霊長類研究所, 教授 (20212194)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords性的二型 / ニホンザル / 排卵 / 発情期 / エストロゲン / プロゲステロン / 遺伝子発現 / RNAseq / フィールド試料 / 性皮腫張 / 性周期 / 性ホルモン / ヒト / PER2遺伝子
Outline of Final Research Achievements

[Purpose] In this study, we try to provide a list of the genes that change the expression levels in phase with oscillation of sex hormones. [Materials&Methods] Blood samples were collected from two Japanese macaques with spontaneous ovulation. The blood concentrations of estradiol and progesterone were measured with time. We extracted RNAs from the blood at the peaks of the hormone concentrations just before and after ovulation, and conducted RNAseq for the four samples. [Progress] We are going to analyze the raw data of RNAseq.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (6 results)

  • [Journal Article] Natural allelic variations of xenobiotic-metabolizing enzymes affect sexual dimorphism in Oryzias latipes2014

    • Author(s)
      Katsumura T., Oda S., Nakagome S., Hanihara T., Kataoka H., Mitani H., Kawamura S., Oota H.
    • Journal Title

      Proceedings of The Royal Society B

      Volume: 281 Issue: 1797 Pages: 1-8

    • DOI

      10.1098/rspb.2014.2259

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Color vision variation as evidenced by hybrid L/M opsin genes in wild populations of trichromatic Alouatta New World monkeys.2014

    • Author(s)
      Matsushita, Y., Oota, H., Welker, B. J., Pavelka, M. S. and Kawamura, S.
    • Journal Title

      International Journal of Primatology

      Volume: 35 Issue: 1 Pages: 71-87

    • DOI

      10.1007/s10764-013-9705-9

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of Monoclonal antibodies to Galß1-4Gal epitopes: a key tool in studies of species-specific glycans expressed in fish, amphibians, and birds.2013

    • Author(s)
      Suzuki N,Nawa D,Tateno H,Yasuda T,Oda S,Mitani H,Nishimaki T, Katsumura T,Oota H,Hanihara T,Oga A,Hirabayashi J,Yamamoto K.
    • Journal Title

      Glycobiology

      Volume: 23 Issue: 1 Pages: 91-105

    • DOI

      10.1093/glycob/cws129

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 薬物代謝酵素の遺伝的多型がメダカの性的二型に与える影響とその進化的考察2014

    • Author(s)
      勝村啓史、尾田正二、三谷啓志、河村正二、太田博樹
    • Organizer
      日本進化学会第16回大阪大会
    • Place of Presentation
      高槻現代劇場(大阪府高槻市)
    • Year and Date
      2014-08-21 – 2014-08-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] メダカ体内受精卵の全身組織切片からの組織学的解析ー受精卵の三次元再構築を中心にー2014

    • Author(s)
      西槙俊之、木森義隆、勝村啓史、尾田正二、埴原恒彦、太田博樹
    • Organizer
      第119回日本解剖学会全国学術集会
    • Place of Presentation
      栃木
    • Related Report
      2013 Research-status Report
  • [Presentation] Naturally occurring variation of CYP xenobiotic enzyme alleles in medaka sheds a new light on sexual dimorphism variation among human populations2013

    • Author(s)
      T. Katsumura, S. Oda, H. Mitani, S. Kawamura, H. Oota
    • Organizer
      19th Japanese Medaka and Zebrafish Meeting
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Reconstructing 3D image based on tissue sections of internally fertilized egg in Oryzias latipes2013

    • Author(s)
      T. Nishimaki, Y. Kimori, T. Katsumura, S. Oda, T. Hanihara, H. Oota
    • Organizer
      19th Japanese Medaka and Zebrafish Meeting
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Collaborative efforts for the establishment of human disease model using Medaka Presentation2013

    • Author(s)
      K. Naruse, Y. Taniguchi, S. Kuninaka, S. Oda, M. Shinya, A. Oga, H. Oota, Y. Kamei
    • Organizer
      1st Zebrafish for Personalized/Precision Medicine Conference
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2013 Research-status Report
  • [Presentation] 動きと組織切片像の数値化によるメダカの全部の定量化

    • Author(s)
      尾田正二、浅香智美、保田隆子、三谷啓志、谷口善仁、太田博樹、勝村啓史、西槙俊之、埴原恒彦、小賀厚徳、木森義隆
    • Organizer
      メダカを使った解析パイプライン~ヒト疾患モデルとしてのメダカ:コンディショナルKOなどを使った多面的解析系の確立~
    • Place of Presentation
      岡崎コンファレンスセンター、愛知
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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