Investigation of Possibility and Environmental Adaptative Mechanism to Create a Resistance Strain for Quorum Sensing Inhibition
| Project/Area Number |
25660062
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied microbiology
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| Research Institution | Kyushu Institute of Technology |
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Principal Investigator |
MAEDA Toshinari 九州工業大学, 生命体工学研究科, 准教授 (00470592)
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| Co-Investigator(Kenkyū-buntansha) |
MOROHOSHI Tomohiro 宇都宮大学, 工学研究院, 准教授 (90361360)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | クォーラムセンシング阻害 / 環境適応機能 / 耐性菌株 / 緑膿菌 / 代謝変換 / クォーラムセンシング / 阻害剤 / 耐性 / 代謝 |
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| Outline of Final Research Achievements |
Inhibition of quorum sensing is a promising approach as a next-generation infection treatment unlike antibiotics which kill bacteria.
In this study, it was investigated if bacteria can have a certain ability to alleviate or avoid repression effect by quorum sensing inhibition. Therefore, a resistant strain to quorum sensing inhibition was screened under the condition in the presence of adenosine as a sole carbon source as utilization of adenosine is required by the function of quorum sensing. As a result, mexR and nalC genes in Pseudomonas aeruginosa were related to the resistance to quorum sensing inhibition and also Pseudomonas aeruginosa was able to biotransform a quorum sensing inhibitor.
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Report
(3 results)
Research Products
(9 results)
