Identification of a secreted factor that regulates nitrogen metabolism in fission yeast

Research Project

Project/Area Number	25660070
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Applied microbiology
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	YASHIRODA Yoko 独立行政法人理化学研究所, 吉田化学遺伝学研究室, 専任研究員 (60360658)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	分裂酵母 / 代謝 / 細胞間情報交換
Outline of Final Research Achievements	We identified a hydroxy fatty acid and an acetoxy-fatty acid that are secreted from fission yeast. In the presence of preferred a nitrogen source like ammonia, yeast prevent permeases to uptake non-preferred nitrogen sources like amino acids. Our study reveals that in the presence of those fatty acids, yeast seems to uptake non-preferred nitrogen sources even in the presence of much ammonia in the media. This result suggests that there exists a novel compound-mediated cell-cell communication system for nitrogen metabolism in fission yeast.

Report

(3 results)