Identification of a secreted factor that regulates nitrogen metabolism in fission yeast
| Project/Area Number |
25660070
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied microbiology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YASHIRODA Yoko 独立行政法人理化学研究所, 吉田化学遺伝学研究室, 専任研究員 (60360658)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 分裂酵母 / 代謝 / 細胞間情報交換 |
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| Outline of Final Research Achievements |
We identified a hydroxy fatty acid and an acetoxy-fatty acid that are secreted from fission yeast. In the presence of preferred a nitrogen source like ammonia, yeast prevent permeases to uptake non-preferred nitrogen sources like amino acids. Our study reveals that in the presence of those fatty acids, yeast seems to uptake non-preferred nitrogen sources even in the presence of much ammonia in the media. This result suggests that there exists a novel compound-mediated cell-cell communication system for nitrogen metabolism in fission yeast.
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Report
(3 results)
Research Products
(2 results)
