| Project/Area Number |
25660087
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
KITANO Yoshikazu 東京農工大学, (連合)農学研究科(研究院), 准教授 (10302910)
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| Co-Investigator(Renkei-kenkyūsha) |
CHIBA Kazuhiro 東京農工大学, 大学院農学研究院, 教授 (20227325)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ペプチド合成 / 無保護アミノ酸 |
|---|
| Outline of Final Research Achievements |
Peptide coupling of unprotected amino acids was examined with an active ester support under biphasic condition. At first, an active ester support which has polyalkoxyphenol ethers and N-hydroxyimide moieties was synthesized. The desired coupling reaction of unprotected amino acids proceeded effectively by using the synthesized active ester compound. In addition, the reusability of the ester active support was verified after using the coupling reaction. It was suggested that this method could be applied to the continuous peptide coupling of unprotected amino acids.
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