Elucidation of the role of exosomes in biological regulatory function of microbiota
Project/Area Number |
25660092
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Food science
|
Research Institution | National Agriculture and Food Research Organization |
Principal Investigator |
AOKI Ayako 独立行政法人農業・食品産業技術総合研究機構, 畜産草地研究所畜産物研究領域, 任期付研究員 (60610368)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | エキソソーム / 腸内細菌 / microRNA / 無菌マウス / 生体機能調節 / miRNA |
Outline of Final Research Achievements |
In this study, I investigated the differences of components and biological functions of serum exosomes between germ-free (GF) and specific pathogen-free (SPF) mice. The microarray analysis for microRNA expression revealed that microRNAs of serum exosomes were expressed diffirentially between them. Furthermore, vein injection of serum exosomes from GF or SPF mice made different mRNA expressions on the spleen and the liver of the exosomes-injected mice. These data suggest that microbiota modulate biological functions via serum exosomes.
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Report
(3 results)
Research Products
(1 results)