Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Outline of Final Research Achievements |
In this study, I investigated the differences of components and biological functions of serum exosomes between germ-free (GF) and specific pathogen-free (SPF) mice. The microarray analysis for microRNA expression revealed that microRNAs of serum exosomes were expressed diffirentially between them. Furthermore, vein injection of serum exosomes from GF or SPF mice made different mRNA expressions on the spleen and the liver of the exosomes-injected mice. These data suggest that microbiota modulate biological functions via serum exosomes.
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