| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
As a basic research for the long-term preservation of bio-tissue and foods under low-temperature condition, observation of ice-crystals which form in a bio-tissue and molecular simulation of the system of proteins and water have been carried out. By both the observations and molecular simulations, irreversible change of the structure of proteins and water were confirmed to happen. From the results of molecular simulations, at -50℃, a molecule of Collagen II increased its length by 7%, while that of Myosin II decreased its length by 1% comparing to the condition at 37℃. The simulation results of Collagen and water system showed that the water molecule in freezing condition intruded in the protein structure. While for the case of Myosin, molecular structure of protein tended to fold in the middle part of the structure. This tendency implies the possibility of destruction of bio tissue such as human mussels during freezing preservation.
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