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Invention of nano delivery systems with food antioxidants in the body.

Research Project

Project/Area Number 25660094
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionTohoku University

Principal Investigator

MIYAZAWA Teruo  東北大学, (連合)農学研究科(研究院), 教授 (20157639)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Kiyotaka  東北大学, 大学院農学研究科, 准教授 (80361145)
KIMURA Fumiko  東北大学, 大学院農学研究科, 助教 (50321980)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsナノデリバリーシステム / ナノ粒子 / 食品成分 / 抗酸化物質 / 動物実験 / 食品科学
Outline of Final Research Achievements

Rise of oxidative stress in the brain is enhanced by the aggregation of amyloid-beta protein and decrease of lipophilic antioxidants. This phenomenon is associated as one factor in the generation of Alzheimer's disease (AD). However, there is no certain treatment or cure for AD. This may be due to the blood brain barrier (BBB), which limits brain uptake of various bioactive compounds (including small molecules). Therefore, in the present study, we prepare the “lipophilic antioxidant encapsulated biodegradable nanoparticles” and challenge to improve brain lipophilic antioxidant concentrations (by decreasing oxidative stress in the brain) by oral intake.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] Comparison of the effects of curcumin and curcumin glucuronide in human hepatocellular carcinoma HepG2 cells.2014

    • Author(s)
      Shoji, M., Nakagawa, K., Watanabe, A., Tsuduki, T., Yamada, T., Kuwahara, S., Kimura, F., Miyazawa T.,
    • Journal Title

      Food Chem

      Volume: 151 Pages: 126-132

    • DOI

      10.1016/j.foodchem.2013.11.021

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential cellular uptake and metabolism of curcuminoids in monocytes/macrophages: regulatory effects on lipid accumulation.2014

    • Author(s)
      Nakagawa, K., Zingg, J.-M., Kim, S. H., Thomas, M. J., Dolnikowski, G. G., Azzi, A., Miyazawa, T., Meydani, M.
    • Journal Title

      Brit. J. Nutr.

      Volume: 112 Issue: 1 Pages: 8-14

    • DOI

      10.1017/s0007114514000567

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] クルクミンの生物学的利用能向上を目指したナノ粒子作製2014

    • Author(s)
      張替 敬裕, 宮澤 大樹, 庄司 求, 仲川 清隆, 藤井 智幸, 宮澤 陽夫
    • Organizer
      日本油化学会第53回年会
    • Place of Presentation
      札幌市
    • Year and Date
      2014-09-09 – 2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] クルクミンおよび類縁体の培養細胞への取り込み:細胞内移行と生理作用発現機構の関係性2014

    • Author(s)
      仲川 清隆, 林 真貴子, 庄司 求, 今野 博行, Jean-Marc Zingg, Angelo Azzi, Mohsen Meydani, 宮澤 陽夫
    • Organizer
      日本ビタミン学会第66回大会
    • Place of Presentation
      姫路市
    • Year and Date
      2014-06-13 – 2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] クルクミン封入ナノ粒子の調製と生物学的利用能向上2014

    • Author(s)
      張替 敬裕, 宮澤 大樹, 庄司 求, 仲川 清隆, 藤井 智幸, 宮澤 陽夫
    • Organizer
      日本農芸化学会平成26年度大会
    • Place of Presentation
      川崎市
    • Related Report
      2013 Research-status Report
  • [Presentation] ルテイン封入ナノ粒子の脳への送達研究2013

    • Author(s)
      宮澤 大樹, 仲川 清隆, 木村 ふみ子, 藤井 智幸, 宮澤 陽夫
    • Organizer
      第47回日本栄養・食糧学会東北支部大会
    • Place of Presentation
      秋田市
    • Related Report
      2013 Research-status Report
  • [Presentation] クルクミングルクロン酸抱合体の生理活性とクルクミンナノ粒子作製2013

    • Author(s)
      張替 敬裕, 宮澤 大樹, 庄司 求, 仲川 清隆, 藤井 智幸, 宮澤 陽夫
    • Organizer
      日本農芸化学会東北支部第148回大会
    • Place of Presentation
      盛岡市
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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