Invention of nano delivery systems with food antioxidants in the body.
| Project/Area Number |
25660094
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Tohoku University |
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Principal Investigator |
MIYAZAWA Teruo 東北大学, (連合)農学研究科(研究院), 教授 (20157639)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Kiyotaka 東北大学, 大学院農学研究科, 准教授 (80361145)
KIMURA Fumiko 東北大学, 大学院農学研究科, 助教 (50321980)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ナノデリバリーシステム / ナノ粒子 / 食品成分 / 抗酸化物質 / 動物実験 / 食品科学 |
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| Outline of Final Research Achievements |
Rise of oxidative stress in the brain is enhanced by the aggregation of amyloid-beta protein and decrease of lipophilic antioxidants. This phenomenon is associated as one factor in the generation of Alzheimer's disease (AD). However, there is no certain treatment or cure for AD. This may be due to the blood brain barrier (BBB), which limits brain uptake of various bioactive compounds (including small molecules). Therefore, in the present study, we prepare the “lipophilic antioxidant encapsulated biodegradable nanoparticles” and challenge to improve brain lipophilic antioxidant concentrations (by decreasing oxidative stress in the brain) by oral intake.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Comparison of the effects of curcumin and curcumin glucuronide in human hepatocellular carcinoma HepG2 cells.2014
Author(s)
Shoji, M., Nakagawa, K., Watanabe, A., Tsuduki, T., Yamada, T., Kuwahara, S., Kimura, F., Miyazawa T.,
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Journal Title
Food Chem.
Volume: 151
Pages: 126-132
DOI
Related Report
Peer Reviewed
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[Journal Article] Differential cellular uptake and metabolism of curcuminoids in monocytes/macrophages: regulatory effects on lipid accumulation.2014
Author(s)
Nakagawa, K., Zingg, J.-M., Kim, S. H., Thomas, M. J., Dolnikowski, G. G., Azzi, A., Miyazawa, T., Meydani, M.
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Journal Title
Brit. J. Nutr.
Volume: 112
Pages: 8-14
DOI
Related Report
Peer Reviewed
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