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Correlation analysis of genetic polymorphism of human bitter-taste receptor TAS2R and that of hepatic detoxification enzyme GST

Research Project

Project/Area Number 25660096
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionTohoku University

Principal Investigator

KOMAI MICHIO  東北大学, (連合)農学研究科(研究院), 教授 (80143022)

Co-Investigator(Kenkyū-buntansha) SHIRAKAWA Hitoshi  東北大学, 大学院農学研究科, 准教授 (40206280)
GOTO Tomoko  東北大学, 大学院農学研究科, 助教 (00342783)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords苦味受容体TAS2R / 遺伝子多型 / アブラナ科植物 / 苦味物質 / 解毒酵素 / 苦味感受性 / 解毒酵素GSTs / 苦味嗜好性
Outline of Final Research Achievements

Many epidemiological studies have shown that isothiocyanate compounds in the cruciferous plant prevents cancer incidence rate. If the taster of this bitter compounds by TAS2R, bitter taste receptor, the intake of this compound may decrease due to its too much bitterness sensation during eating. Another possibility is hepatic glutathione S-transferase (GST) polymorphism. The latter one is involved in the detoxification mechanism of isothiocyanate compounds after eating in the liver, i.e., we cannot eat cruciferous plants if the GST activity is low due to the enzyme polymorphism. Therefore, we analyzed the relationship of TAS2Rs and GSTs polymorphism in human volunteer, and intended to clarify the mechanism involved in the individual difference of cruciferous plant acceptability. Up to now, we found that the SNP of TAS2R 38 had a close relationship to broccoli bitterness.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2014 Other

All Presentation (4 results)

  • [Presentation] アブラナ科野菜の苦味感受性の個人差と苦味レセプターTAS2Rの遺伝子多型に関する研究 (静岡、10月2日)2014

    • Author(s)
      八巻美智子、齋藤弘貴、磯野邦夫、後藤知子、白川仁、駒井三千夫
    • Organizer
      日本味と匂学会第48回大会
    • Place of Presentation
      静岡市
    • Year and Date
      2014-10-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of human TAS2R variations underlying individual difference in the food preference and bitter taste evaluation.2014

    • Author(s)
      Hiroki Saito, Michiko Yamaki, Kunio Isono, Hitoshi Shirakawa, Tomoko Goto, Michio Komai
    • Organizer
      ECRO (European Chemoreception Research Organization) 2014
    • Place of Presentation
      フランス、ディジョン市
    • Year and Date
      2014-09-10 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] ジペプチドの苦味感受性と苦味レセプターTAS2Rの一塩基多型2014

    • Author(s)
      齋藤弘貴、八巻美智子、沼倉悠紀子、磯野邦夫、安達良太、入部マイ子、後藤知子、白川仁、駒井三千夫
    • Organizer
      第68回日本栄養・食糧学会大会(札幌、5月31日)
    • Place of Presentation
      札幌市
    • Year and Date
      2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] ジペプチドの苦味感受性の個人差をもたらす苦味レセプターの一塩基多型

    • Author(s)
      斎藤弘貴、沼倉悠紀子、磯野邦夫、足立良太、入部マイ子、後藤知子、白川仁、駒井三千夫
    • Organizer
      日本味と匂学会 第47回大会
    • Place of Presentation
      仙台市民会館
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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