| Project/Area Number |
25660099
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKAHASHI Naoki 東京大学, 農学生命科学研究科, 教授 (30179501)
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Takuya 東京大学, 大学院農学生命科学研究科, 助教 (90346312)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 催奇形性 / 遺伝子発現 / 哺乳類 / ポリフェノール |
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| Research Abstract |
Contrasting a comprehensive analysis using DNA microarrays, our analysis is simpler and allows the examination of a large number of samples. Information on molecular markers such as the Hox genes under various conditions (exposure-time, -dosage) will allow the prediction of the hazardous nature of unknown factors. In addition, the understanding of the molecular mechanisms common to different teratogenic agents requires the identification of the target genes of Hox and each transcription factor and an understanding of transcription factor networks
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