| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
Interestingly, EGCG treatment for 3, 6, 12 or 18 hours induced a drastic decrease in extracellular PCSK9 level without reduction of PCSK9 mRNA level in HepG2 cells. EGCG treatment for 24 hours induced a significant decrease in extracellular PCSK9 level accompanying with an up-regulation of LDL receptor. EGCG increased LDL receptor mRNA level through the extracellular signal-related kinase and p38 mitogen-activated protein kinase signalling pathways. We found for the first time that EGCG induced a suppression of PCSK9 accompanying with an up-regulation of LDL receptor in HepG2 cells. Furthermore, EGCG induced an activation of LDL receptor or a decrease of PCSK9 level is partially mediated by Annexin A2.
|
