| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
It is known that offspring in mammals, including human, grow and develop by intake of milk, which their mothers biosynthesize and secrete. We hypothesized that milk-derived molecules, which were produced in the gastrointestinal tract of offspring, interact with the nervous system, and focused on peptides derived from lactoferrin, known as a major human milk protein. We found that, among peptides released from human lactoferrin under enzymatic conditions simulating the gastrointestinal tract, a novel peptide exhibited anxiolytic-like effect after oral administration in mice using behavior test. This is the first neuromodulating peptide derived from human lactoferrin. These results imply a new maternal-infant interaction in the nervous system, and further investigation will uncover the biological significance of this milk peptide-mediated interaction.
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