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Sponge-metabolomics for the discovery of new bioactive natural products

Research Project

Project/Area Number 25660163
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Aquatic life science
Research InstitutionThe University of Tokyo

Principal Investigator

TAKADA Kentaro  東京大学, 農学生命科学研究科, 助教 (90455353)

Co-Investigator(Renkei-kenkyūsha) OKUDA Shujiro  新潟大学, 大学院医歯学総合研究科, 准教授 (00512310)
ISE Yuji  名古屋大学, 大学院理学研究科, 特任助教 (20535108)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords海洋天然物 / メタボロミクス / 生物活性物質 / 共生微生物
Outline of Final Research Achievements

Marine sponges are an important source of structurally diverse and biologically active natural products, several of which have inspired the development of therapeutic agents. In this project, 1500 extracts of marine sponges collected in Japanese shallow-sea or deep-sea were analyzed by LC-MS followed by cluster analyses to reveal their chemical profiles. Based on the chemical profiles, we isolated three cytotoxic peptides and three cytotoxic glycolipids from two different marine sponges. Their structures were determined by a combination of chemical methods and spectroscopic data analyses.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (16 results)

All 2015 2014 2013 Other

All Journal Article (11 results) (of which Peer Reviewed: 10 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (5 results) (of which Invited: 4 results)

  • [Journal Article] Structural reappraisal of corticatic acids, biologically active linear polyacetylenes, from a marine sponge of the genus Petrosia2014

    • Author(s)
      K. Takada, S. Okada, S. Matsunaga
    • Journal Title

      Fish. Sci.

      Volume: 80 Issue: 5 Pages: 1057-1064

    • DOI

      10.1007/s12562-014-0776-0

    • NAID

      40020207530

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Lower Homologues of Ahpatinin, Aspartic Protease Inhibitors, from a Marine Streptomyces sp.2014

    • Author(s)
      Y. Sun, K. Takada, Y. Nogi, S. Okada, S. Matsunaga
    • Journal Title

      J. Nat. Prod.

      Volume: 77 Issue: 7 Pages: 1749-1752

    • DOI

      10.1021/np500337m

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Sequestered Fulvinol-related Polyacetylenes in Peltodoris atromaculata.2014

    • Author(s)
      Ciavatta M.L., Nuzzo, G., Takada K., Mathieu V., Kiss R., Villani G, Gavagnin M.
    • Journal Title

      Journal of Natural Products

      Volume: 77 Issue: 7 Pages: 1678-1684

    • DOI

      10.1021/np500298h

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An environmental bacterial taxon with a large and distinct metabolic repertoire2014

    • Author(s)
      Wilson, M. C., Mori, T., Ruckert, C., Uria, A. R., Helf, M. J., Takada, K., Gernert, C., Steffens, U. A. E., Heycke, N., Schmitt, S., Rinke, C., Helfrich, E. J. N., Brachmann, A. O., Gurgui, C., Wakimoto. T., Kracht, M., Crusemann, M., Hentschel, U., Abe, I., Matsunaga, S., Kalinowski, J., Takeyama, H., Piel, J.
    • Journal Title

      Nature

      Volume: 506 Issue: 7486 Pages: 58-62

    • DOI

      10.1038/nature12959

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Revised structure of cyclolithistide A, a cyclic depsipeptide from the marine sponge Discodermia japonica2014

    • Author(s)
      H. Tajima, T. Wakimoto, K. Takada, Y. Ise, I. Abe
    • Journal Title

      J. Nat. Prod.

      Volume: 77 Issue: 1 Pages: 154-158

    • DOI

      10.1021/np400668k

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] On the Assignment of the Absolute Configuration at the Isolated Methyl Branch in Miyakosyne A, Cytotoxic Linear Acetylene, from the Deep-Sea Marine Sponge Petrosia sp.2013

    • Author(s)
      Hitora, Y.; Takada, K.; Matsunaga, S.
    • Journal Title

      Tetrahedron

      Volume: 69 Issue: 52 Pages: 11070-11073

    • DOI

      10.1016/j.tet.2013.11.013

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii2013

    • Author(s)
      K. C. Tan, T. Wakimoto, K. Takada, T. Ohtsuki, N. Uchiyama, Y. Goda, I. Abe
    • Journal Title

      J. Nat. Prod.

      Volume: 76 Issue: 7 Pages: 1388-1391

    • DOI

      10.1021/np400404r

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surugamides, Cyclic Octapeptides with Four D-Amino Acid Residues, from a Marine Streptomyces sp.: LCMS-Aided Inspection of Partial Hydrolysates for the Distinction of D- and L-Amino Acid Residues in the Sequence2013

    • Author(s)
      Takada, K.; Ninomiya A.; Naruse, M.; Sun, Y.; Miyazaki, M.; Nogi, Y.; Okada, S. Matsunaga, S.
    • Journal Title

      J. Org. Chem.

      Volume: 78 Issue: 13 Pages: 6746-6750

    • DOI

      10.1021/jo400708u

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stimulators of adiponenesis from the marine sponge Xestospongia testudinaria2013

    • Author(s)
      Akiyama, T.; Takada, K.; Oikawa, T.; Matsuura, N.; Ise, Y.; Okada, S.; Matsunaga, S.
    • Journal Title

      Tetrahedron

      Volume: 69 Issue: 32 Pages: 6560-6564

    • DOI

      10.1016/j.tet.2013.06.007

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Probable Novel MEP Pathway Inhibitor and Its Binding Protein, IspG2013

    • Author(s)
      Nakagawa K, Takada K, Imamura N
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 77 Issue: 7 Pages: 1449-1454

    • DOI

      10.1271/bbb.130094

    • NAID

      10031190451

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] カイメン由来の多彩な二次代謝産物と共生微生物の関係2013

    • Author(s)
      高田 健太郎、松永茂樹
    • Journal Title

      化学と生物

      Volume: 51 Pages: 333-339

    • NAID

      10031170702

    • Related Report
      2013 Research-status Report
  • [Presentation] カイメンメタボロミクスの有用物質探索への適用2015

    • Author(s)
      高田 健太郎
    • Organizer
      マリンケミカルバイオロジー研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 海綿動物の分類から見る共生微生物および天然物の関係2015

    • Author(s)
      高田 健太郎
    • Organizer
      日本分類学連合
    • Place of Presentation
      東京
    • Year and Date
      2015-01-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 3.Sponge Metabolomics and Challenges for Identification of the Producer of Marine Natural Products2014

    • Author(s)
      Kentaro Takada
    • Organizer
      Korean Society of Pharmacognosy
    • Place of Presentation
      Korea
    • Year and Date
      2014-10-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] カイメンメタボロミクスから難培養性共生微生物への挑戦2014

    • Author(s)
      高田 健太郎
    • Organizer
      天然物パワーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 多彩な海洋天然物と共生微生物の関係

    • Author(s)
      高田 健太郎
    • Organizer
      天然物化学研究会
    • Place of Presentation
      東京農業大学(東京)
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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