| Project/Area Number |
25660209
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Animal production science
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 着床 / 胎盤形成 / 共通遺伝子発現 / トロホブラスト細胞 / 細胞分化誘導 / 国際研究者交流 / 哺乳動物 / 遺伝子発現 / エピジェネテック / 非浸潤性胎盤 / 浸潤性胎盤 / 共通項 |
|---|
| Outline of Final Research Achievements |
To study how placental formation is epigenetically regulated, differences between invasive and non-invasive placentation were studied. In invasive placentation, a transcription factor Cited2 in rat trophoblast Rcho cells was down-regulated, resulting in the differentiation of spongiotrophoblast, instead of trophoblast giant cells. In non-invasive trophoblast, trophoblasts in elongated conceptuses used mechanisms associated with lymphocyte homing, epithelial-mesenchymal transition (EMT) and endogenous retroviruses for their fusogenic activity, all of which have been published.
|
