| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The results of current study showed that probiotics feeding enhanced the responsiveness to Salmonella lipopolysaccharide for induction of expression of 6 avian β-defensins (AvBDs) and 2 cathelicidins in the chick cecum. However, probiotics feeding did not affect significantly the expression of inflammatory cytokines. There are reports showing that probiotics regulate the microflora in the intestine to suppress infection by pathogenic microorganisms, whereas the current study suggests that probiotics enhances the functions to synthesize AvBDs and CATHs. It is suggested that probiotics enhances the innate immunity by antimicrobial peptides in the gut, leading to enhancement of defense ability against pathogenic microbes.
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