Studies on the regulation and function of Ihh during implantation
| Project/Area Number |
25660214
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal production science
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| Research Institution | Kyushu University |
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Principal Investigator |
Yamauchi Nobuhiko 九州大学, (連合)農学研究科(研究院), 准教授 (00363325)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Ihh / 子宮内膜 / ウシ / スフェロイド / P4 / 着床 |
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| Outline of Final Research Achievements |
Hedgehog (Hh) proteins are involved in organogenesis and tumorigenesis by regulation of cell proliferation, differentiation and cell-cell interactions. In mammals, indian hedgehog (Ihh) is up-regulated by P4 and critically mediates uterine receptivity in the mouse. Additionally, expression of Ihh mRNA increased at the implantation period in rat uterus. These results indicate that Ihh expression is important in the uterus during pre-pregnancy. Recently, it was reported that the mouse conditional mutation of Ihh in the uterus during pregnancy has no competency of implantation and decidualization. The report suggested that the Ihh plays a critical role in the implantation through epithelial-stromal cross-talk. However, expression of Ihh in the endometrium of mammalian uterus has not been reported yet without rodents. In this study, we investigated the expression and regulation of Ihh in the bovine endometrium in vivo and in vitro.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Developmental capacity and implantation potential of the embryos with multinucleated blastomeres.2015
Author(s)
Akiyoshi Egashira1, Nobuhiko Yamauchi2, 3, Keiko Tanaka1, Chihiro Mine1, Hitomi Otsubo1, Masao Murakami1, Md. Rashedul Islam2, Misako Ohtsuka1, Naomi Yoshioka1, and Takashi Kuramoto
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Journal Title
J Reprod Dev
Volume: 61
Pages: 595-600
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Development of an in vitro model for the analysis of bovine endometrium using simple techniques.2015
Author(s)
Yamauchi K, Yamauchi N, Yamagami K, Nakamura N, Yamashita S, Islam MR, Tabata S, Yahiro K, Tamura T, Hashizume K, Hattori MA.
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Journal Title
Animal Science Journal
Volume: 6
Pages: 1-6
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Improvement of the cellular quality of cryopreserved bovine blastocysts accompanied by enhancement of the ATP-binding cassette sub-family B member 1 expression.2013
Author(s)
Mori M, Kasa S, Isozaki Y, Kamori T, Yamaguchi S, Ueda S, Kuwano T, Eguchi M, Isayama K, Nishimura S, Tabata S, Yamauchi N, Hattori MA.
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Journal Title
Reproductive Toxicology
Volume: 35
Pages: 17-24
Related Report
Peer Reviewed
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