| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Hedgehog (Hh) proteins are involved in organogenesis and tumorigenesis by regulation of cell proliferation, differentiation and cell-cell interactions. In mammals, indian hedgehog (Ihh) is up-regulated by P4 and critically mediates uterine receptivity in the mouse. Additionally, expression of Ihh mRNA increased at the implantation period in rat uterus. These results indicate that Ihh expression is important in the uterus during pre-pregnancy. Recently, it was reported that the mouse conditional mutation of Ihh in the uterus during pregnancy has no competency of implantation and decidualization. The report suggested that the Ihh plays a critical role in the implantation through epithelial-stromal cross-talk. However, expression of Ihh in the endometrium of mammalian uterus has not been reported yet without rodents. In this study, we investigated the expression and regulation of Ihh in the bovine endometrium in vivo and in vitro.
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