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Experimental mouse model for influenza-associated encephalopathy

Research Project

Project/Area Number 25660221
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionTottori University

Principal Investigator

SUNDEN Yuji  鳥取大学, 農学部, 准教授 (20451403)

Research Collaborator OICHI Marino  
SODA Kosuke  
MORITA Takehito  
HASHIGUCHI Miteki  
SEKIGUCHI Yuka  
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordspathology / influenza / virus / encephalopathy / mouse / cytokine / インフルエンザ / 脳症 / マウス / サイトカイン / 脳脊髄液 / ウイルス / 病理 / 人獣共通感染症
Outline of Final Research Achievements

Influenza-associated encephalopathy (IAE) is a severe neurological disease of infant. The pathogenesis of IAE is not well known and no effective preventive/therapeutic treatment is established. The purpose of present study is to establish a mouse model of IAE through influenza virus challenge experiment. It is demonstrated that the virus-inoculated mouse showed respiratory disease including pneumonia, however, no evidence of neurological disorders and/or brain lesions are observed. Further, direct inoculation of a few viral antigens into brain parenchyma induced high cytokine profiles those are partly similar to the findings of IAE patients.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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