| Project/Area Number |
25660222
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Veterinary medical science
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
ISHII Akihiro 北海道大学, 人獣共通感染症リサーチセンター, 助教 (90421982)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | アレナウイルス / ザンビア / 細胞侵入機構 / 人獣共通感染症 / xenotropism |
|---|
| Outline of Final Research Achievements |
We detected and isolated various species of arenavirus in wild rodent in Zambia. A novel Luna virus strain in mastomys and a novel arenavirus species of Solwezi virus in Grammomys rodents were isolated. To elucidate cellular entry mechanism of Luna virus, Solwezi virus, and previously isolated Lunk virus in African pigmy mouse, the known entry receptor of LAMP-1 for Lassa virus was examined its function. Notably, rodent LAMP-1 was available of the receptor for Luna virus, but not for Solwezi virus and Lunk virus.
|
