| Project/Area Number |
25660227
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
OHAMA Takashi 山口大学, 獣医学部, 准教授 (50579018)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 細胞死 / アポトーシス / オートファジー / ホスファターゼ / リン酸化 / Beclin 1 / 脱リン酸化酵素 |
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| Outline of Final Research Achievements |
There are two types of programed cell death, called apoptosis and autophagy. The purpose of this project is to clarify the mechanism of turnout switch for cells selecting the way to die. We focused on type2A protein phosphatase family, PP2A and PP6, and Beclin 1 that plays important roles for both apoptosis and autophagy. We performed 1) Identification of novel phospho-site of Beclin 1 and its functional analysis, 2) Analysis for the regulatory mechanism of Beclin 1 complex composition by PP6, 3) Analysis for the regulatory mechanism of apoptosis by PP2A.
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