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Mechanism of turnout switch for cell death

Research Project

Project/Area Number 25660227
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionYamaguchi University

Principal Investigator

OHAMA Takashi  山口大学, 獣医学部, 准教授 (50579018)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords細胞死 / アポトーシス / オートファジー / ホスファターゼ / リン酸化 / Beclin 1 / 脱リン酸化酵素
Outline of Final Research Achievements

There are two types of programed cell death, called apoptosis and autophagy. The purpose of this project is to clarify the mechanism of turnout switch for cells selecting the way to die. We focused on type2A protein phosphatase family, PP2A and PP6, and Beclin 1 that plays important roles for both apoptosis and autophagy. We performed 1) Identification of novel phospho-site of Beclin 1 and its functional analysis, 2) Analysis for the regulatory mechanism of Beclin 1 complex composition by PP6, 3) Analysis for the regulatory mechanism of apoptosis by PP2A.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results)

  • [Journal Article] Characterization of SET/I2PP2A Isoforms in Dogs2014

    • Author(s)
      Yabe R, Fujiwara N, Mizuno T, Usui T, Ohama T*, Sato K
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 76 Issue: 9 Pages: 1235-1240

    • DOI

      10.1292/jvms.14-0209

    • NAID

      130004432203

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Protein Phosphatase Methyl Esterase PME-1 protects Protein Phosphatase 2A from ubiquitin/proteasome degradation2015

    • Author(s)
      Yabe R, Miura A, Sato K, Ohama T
    • Organizer
      Europhosphatase 2015
    • Place of Presentation
      Turku, Finland
    • Year and Date
      2015-06-24 – 2015-06-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Regulation of Beclin 1 association with Atg14L and autophagy by PP2A and DAPK32015

    • Author(s)
      Fujiwara N, Usui T, Sato K, Ohama T
    • Organizer
      Europhosphatase 2015
    • Place of Presentation
      Turku, Finland
    • Year and Date
      2015-06-24 – 2015-06-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] The role of PP2A inhibitor SET/I2PP2A in Gastric Cancer2014

    • Author(s)
      Enjoji S, Yoshimura K, Fujiwara N, Oshima H, Oshima M, Usui T, Sato K, Ohama T
    • Organizer
      11th International Conference on Protein Phosphatase
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-11-12 – 2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Protein Phosphatase Methyl Esterase PME-1 protects Protein Phosphatase 2A from ubiquitin/proteasome degradation2014

    • Author(s)
      Yabe R, Miura A, Sato K, Ohama T
    • Organizer
      11th International Conference on Protein Phosphatase
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-11-12 – 2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] The Role of Protein Phosphatase 2A Associated Phospho-site of Beclin 1 on Autophagy2014

    • Author(s)
      Fujiwara N, Usui T, Sato K, Ohama T
    • Organizer
      11th International Conference on Protein Phosphatase
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-11-12 – 2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胃癌におけるPP2A阻害因子SETの役割の解明2014

    • Author(s)
      吉村和大、藤原信行、大島浩子、大島正伸、臼井達哉、大浜剛、佐藤晃一
    • Organizer
      第157回日本獣医学会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] The role of Protein Phosphatase 6 in mammalian autophagy2013

    • Author(s)
      Fujiwara N, Sato K, Ohama T
    • Organizer
      Europhosphatase 2013, Protein Phosphatase in Health and Disease
    • Place of Presentation
      Rehovot, Israel
    • Related Report
      2013 Research-status Report
  • [Presentation] Protein Phosphatase 6はBeclin 1-VPS34複合体を解離させる2013

    • Author(s)
      藤原信行、佐藤晃一、大浜剛
    • Organizer
      細胞内ロジスティクス・シンポジウム
    • Place of Presentation
      淡路夢舞台国際会議場(淡路市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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