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Chemical hazard assessment with the genome-nuclear receptor interaction array system

Research Project

Project/Area Number 25660228
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionEhime University

Principal Investigator

IWATA Hisato  愛媛大学, 沿岸環境科学研究センター, 教授 (10271652)

Research Collaborator YOSHINOUCHI Yuka  愛媛大学, 大学院理工学研究科博士前期課程, 学生
HIRANO Masashi  愛媛大学, 沿岸環境科学研究センター, 特任助教
KIM Eun-Young  Kyung Hee University, Department of Biology, Associate Professor
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords核内受容体 / ビスフェノール類 / 水酸化ポリ塩化ビフェニル / 化学物質 / スクリーニング / 種差
Outline of Final Research Achievements

The aim of this study is to construct an in vitro assay system to screen hazardous environmental chemicals that can transactivate the gene via Baikal seal estrogen receptors (bsERs). We constructed the in vitro reporter gene assay system where a expression vector containing bsERα or bsERβ cDNA and a reporter vector containing ER response element were introduced in COS-1 cells. Using this in vitro assay system, we screened the transactivation potencies of 26 bisphenol A and its analogues (BPs) and 16 hydroxylated polychlorinated biphenyl congeners (OH-PCBs). The results showed that most of the test chemicals were able to activate bsERα and bsERβ.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (91 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (23 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 23 results,  Open Access: 4 results,  Acknowledgement Compliant: 5 results) Presentation (60 results) (of which Int'l Joint Research: 16 results,  Invited: 3 results) Remarks (7 results)

  • [Int'l Joint Research] Kyung Hee University(韓国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Organohalogen compounds in pet dog and cat: Do pets biotransform natural brominated products in food to harmful hydroxlated substances?2016

    • Author(s)
      Mizukawa H, Nomiyama K, Nakatsu S, Iwata H, Yoo J, Kubota A, Yamamoto M, Ishizuka M, Ikenaka Y, Nakayama M.M.S, Kunisue T, Tanabe S
    • Journal Title

      Environmental Science & Technology

      Volume: 50 Issue: 1 Pages: 444-452

    • DOI

      10.1021/acs.est.5b04216

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] In vitro and in silico evaluation of transactivation potencies of avian AHR1 and AHR2 by endogenous ligands: implications for the physiological role of avian AHR22016

    • Author(s)
      Kim, I.S., Hwang, J.H., Hirano, M., Iwata, H. and Kim, E.Y.
    • Journal Title

      Comp. Biochem. Physiol. C.

      Volume: 187 Pages: 1-9

    • DOI

      10.1016/j.cbpc.2016.03.011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Auto-induction mechanism of aryl hydrocarbon receptor 2 (AHR2) gene by TCDD-activated AHR1 AHR2 in the red seabream (Pagrus major)2016

    • Author(s)
      Bak, S. M., Iida, M., Soshilov, A. A., Denison, M. S., Iwata, H. and Kim, E. Y.
    • Journal Title

      Archives of Toxicology

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Haptoglobin genotyping of Vietnamese: global distribution of HPdel, complete deletion allele of the HP gene.2015

    • Author(s)
      Soejima M, Agusa T, Iwata H, Fujihara J, Kunito T, Takeshita H, Lan VT, Minh TB, Takahashi S, Trang PT, Viet PH, Tanabe S, Koda Y.
    • Journal Title

      Legal Medicine

      Volume: 17 Issue: 1 Pages: 14-16

    • DOI

      10.1016/j.legalmed.2014.08.004

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vitro and in silico analyses for predicting hepatic cytochrome p450-dependent metabolic potencies of polychlorinated biphenyls in the Baikal seal2015

    • Author(s)
      Jean Yoo, Masashi Hirano, Hazuki Mizukawa, Kei Nomiyama, Tetsuro Agusa, Eun-Young Kim, Shinsuke Tanab, Hisato Iwata
    • Journal Title

      Environmental Science and Technology

      Volume: 49 Issue: 24 Pages: 14588-14596

    • DOI

      10.1021/acs.est.5b03890

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationship between Arsenic (+3 Oxidation State) Methyltransferase Genetic Polymorphisms and Methylation Capacity of Inorganic Arsenic2015

    • Author(s)
      阿草哲郎, 國頭 恭, Nguyen Minh Tue, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, 藤原純子, 竹下治男, 高橋 真, Pham Hung Viet, 田辺信介, 岩田久人
    • Journal Title

      Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)

      Volume: 70 Issue: 3 Pages: 186-196

    • DOI

      10.1265/jjh.70.186

    • NAID

      130005098973

    • ISSN
      0021-5082, 1882-6482
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In silico analysis of the interaction of avian aryl hydrocarbon receptors and dioxins to decipher isoform-, ligand-, and species-specific activations2015

    • Author(s)
      Hirano M, Hwang JH, Park HJ, Bak SM, Iwata H, Kim EY.
    • Journal Title

      Environ Sci Technol

      Volume: 49 Issue: 6 Pages: 3795-3804

    • DOI

      10.1021/es505733f

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association of XRCC1 polymorphisms with arsenic methylation.2015

    • Author(s)
      Fujiwara, J., Yasuda, T., Iwata, H., Tanabe, S., Takeshita, H.
    • Journal Title

      Archives of Toxicology

      Volume: 1 Issue: 4 Pages: 1-4

    • DOI

      10.1007/s00204-015-1490-0

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enzymatic characterization of in vitro-expressed Baikal seal cytochrome P450 (CYP) 1A1, 1A2, and 1B1: Implication of low metabolic potential of CYP1A2 uniquely evolved in aquatic mammals2015

    • Author(s)
      Iwata H, Yamaguchi K, Takeshita Y, Kubota A, Hirakawa S, Isobe T, Hirano M, Kim EY.
    • Journal Title

      Aquat Toxicol

      Volume: 162 Pages: 138-151

    • DOI

      10.1016/j.aquatox.2015.03.010

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Organohalogens and their hydroxylated metabolites in the blood of pigs from an open waste dumping site in south India: Association with hepatic cytochrome P4502015

    • Author(s)
      Mizukawa H, Nomiyama K, Kunisue T, Watanabe MX, Subramanian A, Iwata H, Ishizuka M, Tanabe S
    • Journal Title

      Environ Res

      Volume: 138 Pages: 255-263

    • DOI

      10.1016/j.envres.2015.02.012

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Blood levels of polychlorinated biphenyls and their hydroxylated metabolites in Baikal seals (Pusa sibirica): Emphasis on interspecies comparison, gender difference and association with blood thyroid hormone levels2014

    • Author(s)
      Imaeda D., Nomiyama K., Kunisue T., Iwata H., Tsydenova O., Amano M., Petrov E.A., Batoev V.B, Tanabe S.
    • Journal Title

      Chemosphere

      Volume: 114 Pages: 1-8

    • DOI

      10.1016/j.chemosphere.2014.03.089

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of persistent organochlorine exposure on the liver transcriptome of the common minke whale (Balaenoptera acutorostrata) from the North Pacific.2014

    • Author(s)
      Niimi, S., Imoto, M., Kunisue, T., Watanabe, M.X., Kim, E.Y., Nakayama, K., Yasunaga, G., Fujise, Y., Tanabe, S., Iwata, H.
    • Journal Title

      Ecotoxicology and Environmental Safety

      Volume: 108 Pages: 95-105

    • DOI

      10.1016/j.ecoenv.2014.06.028

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Toxicological Assessment of Polychlorinated Biphenyls and Their Metabolites in the Liver of Baikal Seal (Pusa sibirica).2014

    • Author(s)
      Nomiyama K, Hirakawa S., Eguchi A., Kanbara C., Imaeda D., Yoo J., Kunisue T., Kim E.Y, Iwata H, Tanabe S.
    • Journal Title

      Environmental Science and Technology

      Volume: 48 Issue: 22 Pages: 13530-13539

    • DOI

      10.1021/es5043386

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Novel role of hnRNP-A2/B1 in modulating aryl hydrocarbon receptor ligand sensitivity2014

    • Author(s)
      S. W. Cho, K. I. Suzuki, Y. Miura, T. Miyazaki, M. Nose, H. Iwata and E. Y. Kim
    • Journal Title

      Arch Toxicol

      Volume: online Issue: 11 Pages: 1-12

    • DOI

      10.1007/s00204-014-1352-1

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transient suppression of AHR activity in early red seabream embryos does not prevent the disruption of peripheral nerve projection by 2,3,7,8-tetrachlorodibenzo-p-dioxin.2014

    • Author(s)
      Iida, M., Bak, S.M., Murkami, Y., Kim, E.Y., Iwata, H.
    • Journal Title

      Aquatic Toxicology

      Volume: 154 Pages: 39-47

    • DOI

      10.1016/j.aquatox.2014.05.001

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Molecular and functional characterization of a novel aryl hydrocarbon receptor isoform, AHR1β in the chicken (Gallus gallus)2013

    • Author(s)
      Lee, J. S., Iwabuchi, K., Nomaru, K., Nagahama, N., Kim, E. Y., Iwata, H
    • Journal Title

      Toxicological Sciences

      Volume: 136(2) Issue: 2 Pages: 450-466

    • DOI

      10.1093/toxsci/kft192

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular evaluation of a new highly sensitive aryl hydrocarbon receptor in ostriches.2013

    • Author(s)
      Fujisawa N, Darwish WS, Ikenaka Y, Kim E, Lee J, Iwata H, Nakayama SMM, Ishizuka M.
    • Journal Title

      Poultry Science

      Volume: 92 Issue: 7 Pages: 1921-1929

    • DOI

      10.3382/ps.2013-03090

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alternative in vitro approach for assessing AHR-mediated CYP1A induction by dioxins in wild cormorant (Phalacrocorax carbo) population2013

    • Author(s)
      Thuruthippalli, L. M., Kubota, A. Kim, E. Y., Iwata, H
    • Journal Title

      Environmental Science and Technology

      Volume: 47(12) Issue: 12 Pages: 6656-6663

    • DOI

      10.1021/es401155g

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sex differences in the accumulation of chlorinated dioxins in the cormorant (Phalacrocorax carbo) : implication of hepatic sequestration in the maternal transfer2013

    • Author(s)
      Kubota, A., Yoneda, K., Tanabe, S., Iwata, H
    • Journal Title

      Environmental Pollution

      Volume: 178 Pages: 300-305

    • DOI

      10.1016/j.envpol.2013.03.001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Potencies of red seabream AHR1- and AHR2-mediated transactivation by dioxins : Implication of both AHRs in dioxin toxicity.2013

    • Author(s)
      Bak, S., Iida, M., Hirano. M., Iwata, H. and Kim, E.Y.
    • Journal Title

      Environ. Sci. Technol.

      Volume: 47(6) Issue: 6 Pages: 2877-2885

    • DOI

      10.1021/es304423w

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of the interaction of constitutive androstane receptor with chemicals and steroid receptor coactivator 1 using surface Plasmon resonance biosensor systems : A case study of the Baikal seal (Pusa sibirica) and mouse.2013

    • Author(s)
      Dau, P.T., Sakai, H., Hirano. M., Ishibashi, H., Tanaka, Y., Kameda, K., Fujino, T., Kim, E,Y. and Iwata, H.
    • Journal Title

      Toxicol. Sci.

      Volume: 131(1) Issue: 1 Pages: 116-127

    • DOI

      10.1093/toxsci/kfs288

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the peripheral nervous system of developing red seabream (Pagrus major)2013

    • Author(s)
      Iida, M.
    • Journal Title

      Aquatic Toxicology

      Volume: 128-129 Pages: 193-202

    • DOI

      10.1016/j.aquatox.2012.12.009

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Toxicokinetics of dioxins and other organochlorine compounds in Japanese people: association with hepatic CYP1A2 expression level2013

    • Author(s)
      Watanabe, M. X.
    • Journal Title

      Environment International

      Volume: 53 Pages: 53-61

    • DOI

      10.1016/j.envint.2012.12.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Past, present, and future perspectives of environmental toxicology at Ehime University: advent of an era of the authentic animal study2016

    • Author(s)
      Iwata, H.
    • Organizer
      International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Assessment of effects of dioxins in the Baikal seal (Pusa Sibirica) by proteome and transcriptome analyses2016

    • Author(s)
      Lauan, M. C., Yoo, J., Agusa, T., Hirano, M., Kim, E. Y. and Iwata, H.
    • Organizer
      International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of a naturally occurring dioxin, 1,3,7-tribromodibenzo-p-dioxin on the mysid transcriptome2016

    • Author(s)
      Hirano, M., Uchida, M., Kusano, T., Arizono, K. and Iwata, H.
    • Organizer
      International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Liver transcriptome analysis to assess the effects of prenatal exposure to bisphenol a of rat offspring2016

    • Author(s)
      Hoa, T. N., Yamamoto, K., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y. and Iwata, H.
    • Organizer
      International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ecological factors drive natural selection pressure affecting avian dioxin receptor genotypes2016

    • Author(s)
      Hwang, J. H., Park, J. Y., Park, H. J., Bak, S. M., Hirano, M., Iwata, H., Park, Y. S. and Kim, E. Y.
    • Organizer
      International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transcriptome analysis to identify adverse outcome pathways mediated by the aryl hydrocarbon receptor in TCDD-treated red seabream embryos2016

    • Author(s)
      Iida, M., Fujii, S., Uhida, M., Nakamura, H., Kagami, Y., Agusa, T., Hirano, M., Bak, S. M., Kim, E. Y. and Iwata, H.
    • Organizer
      International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of prenatal exposure of BPA on the transcriptome in chicken embryos2016

    • Author(s)
      Itoh, S., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y. and Iwata, H.
    • Organizer
      International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hepatic transcriptome analysis to assess the effects of polychlorinated biphenyls on beagle dogs2016

    • Author(s)
      Tamura, S., Yoo, J., Mizukawa, H., Agusa, T., Hirano, M., Eguchi A., Nomiyama, K., Tanabe, S., Kim, E. Y. and Iwata, H.
    • Organizer
      International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Assessment of metabolic potential of polyhlorinated biphenyl congeners in the beagle dog liver by in vitro and in silico approaches2016

    • Author(s)
      Yoo, J., Hirano, M., Nomiyama, K., Kim, E. Y., Tanabe, S. and Iwata, H.
    • Organizer
      International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural preference of OH-PCBs to activate the Baikal Seal estrogen receptors2016

    • Author(s)
      Yoshinouchi, Y., Hirano, M., Nomiyama, K., Tanabe, S., Kim, E. Y. and Iwata, H.
    • Organizer
      International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] OH-PCBsによるバイカルアザラシ エストロゲン受容体α・β転写活性化能の評価2015

    • Author(s)
      芳之内結加,平野将司,野見山桂,田辺信介,金恩英,岩田久人
    • Organizer
      環境ホルモン学会第18回研究発表会
    • Place of Presentation
      自治医科大学地域医療学情報センター(栃木県下野市)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of prenatal exposure to bisphenol A on the liver transcriptome of rat offspring2015

    • Author(s)
      Hoa, N. T., Yamamoto, K., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y. and Iwata, H.
    • Organizer
      環境ホルモン学会第18回研究発表会
    • Place of Presentation
      自治医科大学地域医療学情報センター(栃木県下野市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] In silico and in vitro screening of the effects of PPCPs on mysid ecdysteroid receptor signaling2015

    • Author(s)
      Hirano, M., Ohno, Y. and Iwata, H.
    • Organizer
      環境ホルモン学会第18回研究発表会
    • Place of Presentation
      自治医科大学地域医療学情報センター(栃木県下野市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 鳥類の化学物質感受性を規定する分子機序2015

    • Author(s)
      岩田久人,平野将司, 金 恩英
    • Organizer
      第42回日本毒性学会学術年会(The Japanese Society of Toxicology)
    • Place of Presentation
      ホテル日航金沢(石川県金沢市)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] バイカルアザラシ エストロゲン受容体を介したビスフェノール類によるアンタゴニスト作用の評価2015

    • Author(s)
      芳之内結加、清水沙千子、李 鎮善、平野将司、鈴木賢一、中田晴彦、金 恩英、岩田久人
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Hepatic cytochrome P450-dependent metabolic potency of polychlorinated biphenyls in the baikal seal (Pula sibirica)2015

    • Author(s)
      Yoo, J., Hirano, M., Mizukawa, H., Nomiyama, K., Agusa, T., Kim, E. Y., Tanabe, S. and Iwata, H.
    • Organizer
      18th International Symposium on Pollutant Responses in Marine Organisms
    • Place of Presentation
      クラリオンホテル&コングレス(トロンハイム、ノルウェイ)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of functional xenobiotic-responsive elements controlling AHR2 expression of red seabream (Pagrus major)2015

    • Author(s)
      Bak, S. M., Iida, M., Soshilov, A. A., Denison, M. S., Iwata, H. and Kim, E. Y.
    • Organizer
      18th International Symposium on Pollutant Responses in Marine Organisms
    • Place of Presentation
      クラリオンホテル&コングレス(トロンハイム、ノルウェイ)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hepatic proteome analysis of baikal seals contaminated with dioxins and related compounds2015

    • Author(s)
      Lauan, M. C., Agusa, T., Hirano, M., Iwata, H., Kim, E. Y. and Yoo, J.
    • Organizer
      18th International Symposium on Pollutant Responses in Marine Organisms
    • Place of Presentation
      クラリオンホテル&コングレス(トロンハイム、ノルウェイ)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of hepatic cytochrome P450-dependent metabolic potencies of polychlorinated biphenyls in the caniformia, the baikal seal and the beagle dog.2015

    • Author(s)
      Yoo, J., Mizukawa, H., Nomiyama, K., Kim, E. Y., Tanabe, S. and Iwata, H.
    • Organizer
      18th International Symposium on Pollutant Responses in Marine Organisms
    • Place of Presentation
      クラリオンホテル&コングレス(トロンハイム、ノルウェイ)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vitro and in silico assessment of transactivation potencies of baikal seal estrogen receptors2015

    • Author(s)
      Yoshinouchi, Y., Shimizu, S., Lee, J. S., Hirano, M., Agusa, T., Suzuki, K. T., Nakata, H., Kim, E. Y. and Iwata, H.
    • Organizer
      18th International Symposium on Pollutant Responses in Marine Organisms
    • Place of Presentation
      クラリオンホテル&コングレス(トロンハイム、ノルウェイ)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ecological factors affecting natural selection of avian AHR1 genotypes2015

    • Author(s)
      Hwang, J. H., Park, H. J., Bak, S. M., Hirano, M., Iwata, H., Park, Y. S. and Kim, E. Y.
    • Organizer
      18th International Symposium on Pollutant Responses in Marine Organisms
    • Place of Presentation
      クラリオンホテル&コングレス(トロンハイム、ノルウェイ)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between mRNA expressionlevel and SNPs of As3MT in residents from arsenic-contaminated areas in Vietnam.2015

    • Author(s)
      Agusa, T., Kunito, T., Tue, N.M., Lan, V.T., Minh, T.B., Trang, P.T., Fujihara, J., Takeshita, H., Takahashi, S., Viet, P.H., Tanabe, S., Iwata, H.
    • Organizer
      Society of Toxicology (SOT) 54th Annual Meeting
    • Place of Presentation
      サンディエゴ、アメリカ
    • Year and Date
      2015-03-25
    • Related Report
      2014 Research-status Report
  • [Presentation] The autoinduction mechanism of aryl hydrocarbon receptor 2 (AhR2) through TCDD-activated AhR1/2 in the red seabream (Pagrus major).2015

    • Author(s)
      Bak, S.M., Kim, E.Y., Iida, M., Iwata, H.
    • Organizer
      Society of Toxicology (SOT) 54th Annual Meeting
    • Place of Presentation
      サンディエゴ、アメリカ
    • Year and Date
      2015-03-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Strain-differences in the proteome of dioxin-sensitive and -resistant mice treated with 2,3,7,8-tetrabromodibenzo-p-dioxin.2015

    • Author(s)
      Nguyen, T., Lauan, M., Yoo, J., Iida, M., Agusa, T., Kim, E.Y., Miyazaki, T., Nose, M., Iwata, H.
    • Organizer
      Society of Toxicology (SOT) 54th Annual Meeting
    • Place of Presentation
      サンディエゴ、アメリカ
    • Year and Date
      2015-03-24
    • Related Report
      2014 Research-status Report
  • [Presentation] RNA-Seq analysis of the mysid crustacean transcriptome treated with naturally occurring 1,3,7-tribromodibenzo-p-dioxin.2015

    • Author(s)
      Hirano, M., Uchida, M., Kusano, T., Arizono, K., Iwata, H.
    • Organizer
      Society of Toxicology (SOT) 54th Annual Meeting
    • Place of Presentation
      サンディエゴ、アメリカ
    • Year and Date
      2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Effects of a naturally occurring dioxin, 1,3,7-tribromodibenzo-p-dioxin on the mysid transcriptome2014

    • Author(s)
      Hirano, M., Uchida, M., Kusano, T., Arizono, K., Iwata, H.
    • Organizer
      環境ホルモン学会 第17回研究発表会
    • Place of Presentation
      東京都文京区、日本
    • Year and Date
      2014-12-10
    • Related Report
      2014 Research-status Report
  • [Presentation] パスウェイ解析によるTCDD曝露したマダイ胚のトランスクリプトームへの影響評価2014

    • Author(s)
      飯田 緑、藤井 聡、内田雅也、中村 浩、鏡 良弘、Bak Su-Min、金 恩英、岩田久人
    • Organizer
      環境ホルモン学会 第17回研究発表会
    • Place of Presentation
      東京都文京区、日本
    • Year and Date
      2014-12-10
    • Related Report
      2014 Research-status Report
  • [Presentation] ポリ塩化ビフェニル(PCBs)曝露によるイヌ異物代謝酵素シトクロムP450への影響2014

    • Author(s)
      田村沙弥、Yoo Jean、水川葉月、阿草哲郎、平野将司、野見山桂、田辺信介、金 恩英、岩田久人
    • Organizer
      環境ホルモン学会 第17回研究発表会
    • Place of Presentation
      東京都文京区、日本
    • Year and Date
      2014-12-10
    • Related Report
      2014 Research-status Report
  • [Presentation] バイカルアザラシ エストロゲン受容体α・β転写活性化能の評価:種差とE2誘導等価係数2014

    • Author(s)
      芳之内結加、清水沙千子、李 鎮善、平野将司、阿草哲郎、鈴木賢一、中田晴彦、金 恩英、岩田久人
    • Organizer
      環境ホルモン学会 第17回研究発表会
    • Place of Presentation
      東京都文京区、日本
    • Year and Date
      2014-12-09
    • Related Report
      2014 Research-status Report
  • [Presentation] Functional characterization of the clathrin as a novel regulator of ecdysone receptor signaling pathway2014

    • Author(s)
      Hirano, M., Suzuki, K.T., Iwata、H.
    • Organizer
      環境ホルモン学会 第17回研究発表会
    • Place of Presentation
      東京都文京区、日本
    • Year and Date
      2014-12-09
    • Related Report
      2014 Research-status Report
  • [Presentation] バイカルアザラシ (Pusa sibirica) における水酸化PCBsの毒性影響評価2014

    • Author(s)
      野見山桂、平川周作、江口哲史、今枝大輔、Yoo Jean、国末達也、岩田久人、田辺信介
    • Organizer
      環境ホルモン学会 第17回研究発表会
    • Place of Presentation
      東京都文京区、日本
    • Year and Date
      2014-12-09
    • Related Report
      2014 Research-status Report
  • [Presentation] バイカルアザラシ エストロゲン受容体α・β転写活性化能の評価:in vitro ・ in silico法によるリガンド作用機序の解明2014

    • Author(s)
      芳之内結加、清水沙千子、李 鎮善、平野将司、阿草哲郎、鈴木賢一、中田晴彦、金 恩英、岩田久人
    • Organizer
      環境ホルモン学会 第17回研究発表会
    • Place of Presentation
      東京都文京区、日本
    • Year and Date
      2014-12-09
    • Related Report
      2014 Research-status Report
  • [Presentation] ウミガメ類におけるヒ素化合物の蓄積特性2014

    • Author(s)
      阿草哲郎、高木 梢、Todd W. Miller、久保田領志、阿南弥寿美、岩田久人、田辺信介
    • Organizer
      第20回ヒ素シンポジウム
    • Place of Presentation
      千葉県銚子市、日本
    • Year and Date
      2014-12-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Ecological factors as pressure of natural selection of AhR genotypes in avian species2014

    • Author(s)
      Hwang, J.H., Park, H.J., Park, J.Y., Bak, S.M., Park, Y.S., Hirano, M., Kim, E.Y., Iwata, H.
    • Organizer
      DIOXIN Madrid 2014 / 34th International Symposium on Halogenated Persistent Organic Pollutants
    • Place of Presentation
      マドリード、スペイン
    • Year and Date
      2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] In vitro and in silico assessment of transactivation potencies of Baikal seal estrogen receptors αand β by persistent organic pollutants and bisphenols2014

    • Author(s)
      Yoshinouchi, Y., Shimizu, S., Suzuki, K., Lee, J.S., Nakata, H., Hirano, M., Kim, E.Y., Agusa, T., Iwata, H.
    • Organizer
      DIOXIN Madrid 2014 / 34th International Symposium on Halogenated Persistent Organic Pollutants
    • Place of Presentation
      マドリード、スペイン
    • Year and Date
      2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Effects of polychlorinated biphenyls on the expression of cytochrome P450s in beagle dogs2014

    • Author(s)
      Tamura, S., Yoo, J., Nomiyama, K., Mizukawa, H., Tanabe, S., Agusa, T., Kim, E.Y., Hirano, M., Iwata, H.
    • Organizer
      DIOXIN Madrid 2014 / 34th International Symposium on Halogenated Persistent Organic Pollutants
    • Place of Presentation
      マドリード、スペイン
    • Year and Date
      2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Isoform specific induction of aryl hyrocarbon receptor by TCDD in the red seabream (Pagrus major)2014

    • Author(s)
      Bak, S.M., Iida, M., Iwata, H., Kim, E.Y.
    • Organizer
      DIOXIN Madrid 2014 / 34th International Symposium on Halogenated Persistent Organic Pollutants
    • Place of Presentation
      マドリード、スペイン
    • Year and Date
      2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 海棲高等動物はどのように水銀を解毒しているのか?2014

    • Author(s)
      阿草哲郎, 安木進也, 池本徳孝, 國頭 恭, 馬場徳寿, 田辺信介, 岩田久人
    • Organizer
      第33回生体と金属・化学物質に関する研究会(チョークトーク2014)
    • Place of Presentation
      神奈川県藤沢市、日本
    • Year and Date
      2014-08-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 海棲哺乳類の肝臓におけるHg結合タンパク質2014

    • Author(s)
      阿草哲郎,安木進也,池本徳孝,國頭 恭,馬場徳寿,田辺信介,岩田久人
    • Organizer
      第25回日本微量元素学会学術集会
    • Place of Presentation
      岡山県岡山市、日本
    • Year and Date
      2014-07-03 – 2014-07-04
    • Related Report
      2014 Research-status Report
  • [Presentation] AS3MT遺伝子多型と無機ヒ素のメチル化能力との関係2014

    • Author(s)
      阿草哲郎, 國頭 恭, Nguyen Minh Tue, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, 藤原純子, 竹下治男, 高橋 真, Pham Hung Viet, 田辺信介, 岩田久人
    • Organizer
      第84回日本衛生学会学術総会
    • Place of Presentation
      岡山県岡山市、日本
    • Year and Date
      2014-05-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] DDTs ・ビスフェノール類によるバイカルザラシ・マウスエストロゲン受容体転写活性化能の評価2014

    • Author(s)
      芳之内結加,清水沙千子,李 鎮善,平野将司,阿草哲郎,鈴木賢一,中田晴彦,金 恩英,岩田久人
    • Organizer
      第23回環境化学討論会
    • Place of Presentation
      京都府京都市、日本
    • Year and Date
      2014-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] キタオットセイ(Callorhinus ursinus)の肝臓における水銀結合タンパク質の探索2014

    • Author(s)
      阿草哲郎,安木進也,池本徳孝,國頭 恭,馬場徳寿,田辺信介,岩田久人
    • Organizer
      第23回環境化学討論会
    • Place of Presentation
      京都府京都市、日本
    • Year and Date
      2014-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] In vitro approach to predict AHR-mediated CYP1A induction by dioxins in cormorant population2013

    • Author(s)
      Iwata, H., Thuruthippalli, L. M., Kubota, A. and Kim, E. Y.
    • Organizer
      The XIII International Congress of Toxicology 2013
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] In silico analysis of avian AHRs to decipher the molecular basis for interspecies diffrences in responses to dioxins2013

    • Author(s)
      Hirano, M., Bak, S. M., Iwata, H. and Kim, E. Y.
    • Organizer
      The XIII International Congress of Toxicology 2013
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Identification of quantitative trait loci (QTL) associated with inorganic arsenic metabolism using recombinant inbred strains of mice2013

    • Author(s)
      Agusa, T., Komori, H., Soga, Y., Nose, M., Mori, S., Kubota, R., Tanabe, S. and Iwata, H.
    • Organizer
      The XIII International Congress of Toxicology 2013
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Identification and functional characterization of a novel chicken aryl hydrocarbon receptor isoform, 2nd AHR12013

    • Author(s)
      Lee, J. S., Iwabuchi, K., Nomaru, K., Nagahama, N., Kim, E. Y. and Iwata, H.
    • Organizer
      The XIII International Congress of Toxicology 2013
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Effects of aryl hydrocarbon receptor and transcriptional co-factor(s) on transactivation in MRL/lpr and C3H/lpr mouse strains2013

    • Author(s)
      Cho, S. W., Kim, E. Y., Suzuki, K., Miura, Y., Iwata, H., Miyazaki, T. and Nose, M.
    • Organizer
      The XIII International Congress of Toxicology 2013
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Isoform-specific responses of aryl hydrocarbon receptor to dioxins in red seabream (Pagrus major)2013

    • Author(s)
      Bak, S. M., Kim, E. Y., Iida, M. and Iwata, H.
    • Organizer
      The XIII International Congress of Toxicology 2013
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Identification of cytochrome P450 enzymes in phenobarbital-treated mouse liver microsomes using 2-DE and MALDI-TOF/TOF2013

    • Author(s)
      Lauan, M. C., Suzuki, K., Agusa, T. and Iwata, H.
    • Organizer
      3rd International Conference on Proteomics and Bioinformatics
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Effect of aryl hydrocarbon receptor variants and hnRNPA2/B1 on dioxin-induced cyp1a1 transactivation in MRL/lpr and C3H/lpr2013

    • Author(s)
      Cho, S. W., Suzuki, K. I., Miura, Y., Watanabe, M., Miyazaki, T., Nose, M., Iwata, H. and Kim, E. Y.
    • Organizer
      The 33rd International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN2013)
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Isoform-specific transactivation and autoinduction of aryl hydrocarbon receptors by dioxins in the red seabream (Pagrus major)2013

    • Author(s)
      Bak, S. M., Iida, M., Iwata, H. and Kim, E. Y.
    • Organizer
      The 33rd International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN2013)
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Thyroid hormone-mediated effects of dioxins in wild Baikal seals (Pusa sibirica)2013

    • Author(s)
      Iwata, H., Hirakawa, S., Eguchi, A., Imaeda, D., Kunisue, T., Kim, E. Y., Kannan, K., Petrov, E. A., Batoev, V. B. and Tanabe, S.
    • Organizer
      The 33rd International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN2013)
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBs) in the Baikal seals and implication from toxicogenomic approach2013

    • Author(s)
      Nomiyama, K., Eguchi, A., Hirakawa, S., Kanbara, C., Imaeda, D., Kim, E. Y., Iwata, H. and Tanabe, S.
    • Organizer
      The 33rd International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN2013)
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Functional characterization of aryl hydrocarbon receptor from the polar bear (Ursus maritimus)2013

    • Author(s)
      Hwang, J. H., Jeong, L. R., Kannan, K., Evans T. J., Iwata, H. and Kim, E. Y.
    • Organizer
      The 33rd International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN2013)
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] In vitro and In silico analyses to predict the effects of environmental chemicals through the mysid ecdysteroid receptor signaling pathway2013

    • Author(s)
      Hirano, M., Ishibashi, H., Kim, E. Y., Arizono, K. and Iwata, H.
    • Organizer
      The 33rd International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN2013)
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Homology modeling and ligand docking simulations of avian AhRs to decipher the interspecies differences in responses to dioxins2013

    • Author(s)
      Hirano, M., Kim, E. Y., Bak, S. M. and Iwata, H.
    • Organizer
      The 33rd International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN2013)
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] In silico 解析による化学物質と核内受容体・シトクロムP450の相互作用の評価2013

    • Author(s)
      岩田久人,平野将司, Kim Eun-Young
    • Organizer
      環境ホルモン学会 第16回研究発表会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] TCDD曝露したマダイ胚のトランスクリプトーム解析2013

    • Author(s)
      飯田 緑,藤井 聡,内田雅也,中村 浩,鏡 良弘,Bak Su-Min,Kim Eun-Young,島 康洋,岩田久人
    • Organizer
      環境ホルモン学会 第16回研究発表会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Identification of amino acid residues critical for ligand binding and transactivation in ecdysone receptor2013

    • Author(s)
      Hirano, M., Ishibashi, H., Kim, E. Y., Arizono, K. and Iwata, H.
    • Organizer
      環境ホルモン学会 第16回研究発表会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] ホッキョクグマのシトクロムP450 1Aおよび2BによるPCBs代謝能力の評価2013

    • Author(s)
      古池 幸,平野将司,鈴木賢一,Yoo Jean,阿草哲郎,Thomas J. Evans,Kurunthachalam Kannan,岩田久人
    • Organizer
      環境ホルモン学会 第16回研究発表会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Remarks] 岩田研究室のサイト日本語版

    • URL

      http://ecotoxiwata.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 岩田研究室のサイト英語版

    • URL

      http://ecotoxiwata.jp/en/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 岩田研究室のウェブサイト日本語版

    • URL

      http://ecotoxiwata.jp/

    • Related Report
      2014 Research-status Report
  • [Remarks] 岩田研究室のウェブサイト英語版

    • URL

      http://ecotoxiwata.jp/en/index.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 愛媛大学 沿岸環境科学研究センター 環境毒性学(岩田)研究室 日本語版

    • URL

      http://ecotoxiwata.jp/

    • Related Report
      2013 Research-status Report
  • [Remarks] 愛媛大学 沿岸環境科学研究センター 環境毒性学(岩田)研究室 英語版

    • URL

      http://ecotoxiwata.jp/en/

    • Related Report
      2013 Research-status Report
  • [Remarks] 愛媛大学「最先端研究紹介」

    • URL

      http://www.ehime-u.ac.jp/research/infinity/detail.html?new_rec=9116

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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