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In vivo molecular imaging of viral encephalitis

Research Project

Project/Area Number 25660229
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionNagasaki University

Principal Investigator

HAYASAKA Daisuke  長崎大学, 熱帯医学研究所, 助教 (10346926)

Co-Investigator(Renkei-kenkyūsha) FUCHIGAMI Takeshi  長崎大学, 医歯薬総合研究科(薬学系), 准教授 (30432206)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords分子イメージング / 日本脳炎ウイルス / ダニ媒介性脳炎ウイルス / ナイロウイルス / SFTSウイルス / マウス / 18F-FDG / ポジトロン断層法(PET) / マウスモデル
Outline of Final Research Achievements

In this study, we demonstrated in vivo molecular imaging of virus-infected mice. We inoculated encephalitis viruses (Japanese encephalitis virus and Tick-borne encephalitis virus), Severe fever with thrombocytopenia virus (SFTSV) and newly isolated Nairovirus (TFLV) in each susceptible mouse. Following encephalitis virus infections, decrease of 18F-FDG uptakes were observed in the brains of virus-infected mice compared with mock-infected mice. On the other hand, following infections with SFTSV and TFLV, significant uptakes of 18F-FDG were observed in the small intestines of virus-infected mice but not in mock-infected mice. These data will provide useful information for further study of molecular imaging in the field of virology.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (5 results)

  • [Journal Article] A unique amino acid substitution in NS2A protein of Japanese encephalitis virus affects virus propagation in vitro but not in vivo2015

    • Author(s)
      Yuki Takamatsu, Kouichi Morita, Daisuke Hayasaka
    • Journal Title

      Journal of Virology

      Volume: 89(11) Issue: 11 Pages: 6126-6130

    • DOI

      10.1128/jvi.00370-15

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Therapeutic effect of post-exposure treatment with antiserum on severe fever with thrombocytopenia syndrome (SFTS) in a mouse model of SFTS virus infection2015

    • Author(s)
      Satoshi Shimada, Guillermo Posadas-Herrera , Kotaro Aoki, Kouichi Morita, Daisuke Hayasaka
    • Journal Title

      Virology

      Volume: 482 Pages: 19-27

    • DOI

      10.1016/j.virol.2015.03.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Protective role of TNF-α, IL-10 and IL-2 in mice infected with the Oshima strain of Tick-borne encephalitis virus.2014

    • Author(s)
      Tun MM, Aoki K, Senba M, Buerano CC, Shirai K, Suzuki R, Morita K, Hayasaka D.
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 5344-5344

    • DOI

      10.1038/srep05344

    • NAID

      120006986532

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Type-I interferon response affects an inoculation dose-independent mortality in mice following Japanese encephalitis virus infection2014

    • Author(s)
      Kotaro Aoki, Satoshi Shimada, Dash Sima Simantini, Mya Myat Ngwe Tun, Corazon C Buerano, Kouichi Morita, Daisuke Hayasaka
    • Journal Title

      Virology Journal

      Volume: 11:105 Issue: 1 Pages: 1-7

    • DOI

      10.1186/1743-422x-11-105

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pathologic Potential of Variant Clones of the Oshima Strain of Far-Eastern Subtype Tick-Borne Encephalitis Virus2014

    • Author(s)
      Le Xuan Luat, Mya Myat Ngwe Tun, Corazon C. Buerano, Kotaro Aoki, Kouichi Morita, Daisuke Hayasaka
    • Journal Title

      Tropical Medicine and Health

      Volume: 42 Issue: 1 Pages: 15-23

    • DOI

      10.2149/tmh.2013-27

    • NAID

      130003392440

    • ISSN
      1348-8945, 1349-4147
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] TNF-α acts as an immunoregulator in the mouse brain by reducing the incidence of severe disease following Japanese encephalitis virus infection.2013

    • Author(s)
      Hayasaka D, Shirai K, Aoki K, Nagata N, Simantini DS, Kitaura K, Takamatsu Y, Gould E, Suzuki R, Morita K.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 8 Pages: 1-18

    • DOI

      10.1371/journal.pone.0071643

    • NAID

      120006986128

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] TNF-α and IL-10 reduce the incidence of mortality in mice infected with Tick-borne encephalitis virus2014

    • Author(s)
      Mya Myat Ngwe Tun, Kotaro Aoki, Masachika Senba, Corazon C. Buerano, Kenji Shirai, Ryuji Suzuki, Kouichi Morita and Daisuke Hayasaka
    • Organizer
      The 13th Awaji International Forum on Infection and Immunity, Nara
    • Place of Presentation
      奈良県、奈良市、奈良県新公会堂
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 重症熱性血小板減少症候群(SFTS)ウイルス感染マウスモデルを用いた抗血清および薬剤効果の検討2014

    • Author(s)
      早坂大輔、嶋田聡、Guillermo Posadas Herrera、森田公一
    • Organizer
      第51回ウイルス学会九州支部総会
    • Place of Presentation
      鹿児島県、鹿児島市、城山観光ホテル
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] ダニ媒介性脳炎ウイルス感染におけるTNF-α、IL-10およびIL-2応答の役割2014

    • Author(s)
      Mya Myat Ngwe Tun、青木康太郎、千馬正敬、森田公一、早坂大輔
    • Organizer
      第49回日本脳炎ウイルス生態学研究会
    • Place of Presentation
      山口県、山口市、ホテルニュー田中
    • Year and Date
      2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] フラビウイルスの分子イメージング

    • Author(s)
      早坂大輔、淵上剛志、森田公一
    • Organizer
      第48回日本脳炎ウイルス生態学研究会
    • Place of Presentation
      熱海市、ニューウェルシティ湯河原、神奈川県
    • Related Report
      2013 Research-status Report
  • [Presentation] フラビウイルス脳炎の分子イメージング

    • Author(s)
      早坂大輔、淵上剛志、森田公一
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜市、岐阜大学、岐阜県
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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