Spatiotemporal exploration of vascular inflammation during the development of atherosclerosis

• Project/Area Number: 25660233
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Kitasato University
• Principal Investigator: YAMAWAKI Hideyuki 北里大学, 獣医学部, 教授 (60399607)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 薬理学 / 血管 / 病態

Outline of Final Research Achievements

In this project, I aimed to explore the mechanisms for the development of atherosclerosis that is a major risk for ischemic cardiovascular diseases including myocardial infarction and stroke. The major finding of this study is the identification of the novel cytokines that are responsible for the key pathological processes for the development of atherosclerosis including vascular inflammatory response, proliferation and migration.

Research Products

• [Journal Article] Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells. (2014)
  • Author(s): Usui T, Naruo A, Okada M, Hayabe Y, and Yamawaki H.
  • Journal Title: Acta Physiol (Oxf) Volume: In Press Issue: 2 Pages: 385-394
  • DOI: 10.1111/apha.12249
  • Peer Reviewed / Open Access
• [Presentation] Brain-derived neurotrophic factor (BDNF) stimulates proliferation of vascular smooth muscle cells (2015)
  • Author(s): Otani K, Okada M, Yamawaki H.
  • Organizer: The 88th Annual Meeting of The Japanese Pharmacological Society
  • Place of Presentation: Nagoya Congress Center (Nagoya city)
  • Year and Date: 2015-03-18
• [Presentation] Brain-derived neurotrophic factor promotes angiogenesis via oxidative stress in human vascular endothelial cells: Implication for atherogenesis?
  • Author(s): Hideyuki Yamawaki
  • Organizer: 第39回日本微小循環学会総会（AKPS研究集会共催）
  • Place of Presentation: 北里大学(東京都港区）
  • Invited
• [Presentation] Brain-derived neurotrophic factor (BDNF)による血管新生制御メカニズムの解明
  • Author(s): 臼井達哉、成尾明浩、岡田宗善、山脇英之
  • Organizer: 北里大学第26回バイオサイエンスフォーラム
  • Place of Presentation: 北里大学(神奈川県相模原市)
• [Presentation] Brain-derived neurotrophic factor (BDNF)は酸化ストレス産生を介して血管新生を促進する
  • Author(s): 臼井達哉、成尾明浩、岡田宗善、山脇英之
  • Organizer: 第156回日本獣医学会学術集会
  • Place of Presentation: 岐阜大学(岐阜県岐阜市)
• [Presentation] Effects of fatty acid-binding protein(FABP)4 on proliferation of vascular smooth muscle cell
  • Author(s): Sekiguchi A, Kazama K, Okada M, and Yamawaki H.
  • Organizer: The 87th Annual Meeting of The Japanese Pharmacological Society
  • Place of Presentation: 東北大学(宮城県仙台市)
• [Presentation] Nesfatin-1, a novel adipocytokine, stimulates proliferation of vascular smooth muscle cells
  • Author(s): Hayabe Y, Usui T, Okada M, and Yamawaki H.
  • Organizer: The 87th Annual Meeting of The Japanese Pharmacological Society
  • Place of Presentation: 東北大学(宮城県仙台市)
• [Presentation] アディポサイトカインchemerinは血管平滑筋細胞の増殖及び遊走を促進する
  • Author(s): 國本秀瑞垂、高井瑞穂、岡田宗善、山脇英之
  • Organizer: 第23回日本循環薬理学会
  • Place of Presentation: 福岡大学(福岡県福岡市)
• [Remarks] 北里大学獣医薬理学研究室ホームページ
  • URL: http://www2.vmas.kitasato-u.ac.jp/pharmacology/index.html
• [Remarks] 北里大学獣医薬理学研究室ホームページ
  • URL: http://www2.vmas.kitasato-u.ac.jp/pharmacology/