| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Cancers are hierarchically organized by cancer stem cells, thereby creating various features of cancers. The purpose of this study was to elucidate the role of clock genes that function as molecular networks for circadian rhythms in the hierarchical organization of cancers. Analysis for a human breast cancer cell line revealed that glucocorticoids from the adrenal glands and a clock gene, per1, were crucial factors to maintain the functions of cancer stem cells. The present study provides the possibility that a new concept of chronotherapy could be established and applied to cancers in humans and animals.
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