Molecular analysis for the hierarchical organization of cancer stem cells based on clock genes
| Project/Area Number |
25660236
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
OHMORI Keitaro 東京農工大学, (連合)農学研究科(研究院), 講師 (20466915)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 腫瘍 / 癌 / 時計遺伝子 |
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| Outline of Final Research Achievements |
Cancers are hierarchically organized by cancer stem cells, thereby creating various features of cancers. The purpose of this study was to elucidate the role of clock genes that function as molecular networks for circadian rhythms in the hierarchical organization of cancers. Analysis for a human breast cancer cell line revealed that glucocorticoids from the adrenal glands and a clock gene, per1, were crucial factors to maintain the functions of cancer stem cells. The present study provides the possibility that a new concept of chronotherapy could be established and applied to cancers in humans and animals.
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Report
(3 results)
Research Products
(4 results)
