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Investigation of unknown transdifferentiation mechanisms of cutaneous epithelial tumor and related genes

Research Project

Project/Area Number 25660237
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

NISHIFUJI Koji  東京農工大学, (連合)農学研究科(研究院), 准教授 (20365422)

Co-Investigator(Kenkyū-buntansha) SHIROTA Kinji  麻布大学, 獣医学部, 教授 (70149322)
代田 欣二  麻布大学, 獣医学部, 教授 (70147974)
Co-Investigator(Renkei-kenkyūsha) OHYAMA Manabu  慶應義塾大学, 医学部, 准教授 (10255424)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsネスチン / 幹細胞 / 毛包 / コンディショナルノックアウトマウス / 皮膚腫瘍 / 神経堤細胞 / 創傷治癒
Outline of Final Research Achievements

In this study, we investigated distribution and differentiation potential of nestin-expressing cells in normal skin, cutaneous tumor and wounded skin. The nestin-expressing spindle cells and pericytes are distributed in dermal papilla, as well as dermis surrounding cutaneous epithelial tumor and wounded skin. In addition, we found that keratinocytes in outer root sheath cells, keratoacanthoma and wounded skin are daughter cells of nestin-expressing cells. These findings imply that nestin-expressing spindle cells contribute to keratinocyte proliferation, and some of keratinocytes in hair follicle and cutaneous epithelial tumors consist of daughter cells of the neural crest stem cells.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Trichoblastoma with Abundant Plump Stromal Cells in a Dog2014

    • Author(s)
      Minesige T, Yasuno K, Sugahara G, Tomishita Y, Shimokawa N, Kamiie J, Nishifuji K, Shirota K
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 76 Issue: 5 Pages: 735-739

    • DOI

      10.1292/jvms.13-0516

    • NAID

      130003391265

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Distribution of nestin-expressing cells in normal hair follicle and epithelial tumors in dogs2013

    • Author(s)
      Wang YH, Ide K, Shirota K, Nishifuji K
    • Organizer
      3rd Asian Meetings of Animal Medicine Specialties
    • Place of Presentation
      インドネシア国ボゴール市
    • Related Report
      2013 Research-status Report
  • [Remarks]

    • URL

      http://kenkyu-web.tuat.ac.jp/Profiles/15/0001474/profile.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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