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Changes of DNA profile in canine granular tumor cells transformed to melanoma cells

Research Project

Project/Area Number 25660244
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Veterinary medical science
Research InstitutionNippon Veterinary and Life Science University

Principal Investigator

BONKOBARA Makoto  日本獣医生命科学大学, 獣医学部, 准教授 (50343611)

Project Period (FY) 2013-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords顆粒細胞腫 / 黒色腫 / 形質転換機構 / 遺伝子動態 / 犬 / 顆粒細胞腫瘍
Research Abstract

Gene profile was examined in 3 passages of granular cell tumor (GCT), 3 masses developed on nude mouse with GCT and 3 established malignant melanoma cells from oral, neil bed and ocular. Genes related to cell proliferation signaling pathway (PI3K, MAPK, PPAR) and pathways in cancer were significantly increased in GCT with advanced passages, whereas genes related to oxidative phosphorylation were significantly decreased. Significant increase of genes related to cell proliferation signaling pathway (VEGF etc), pathways in cancer, gap and tight junction, and oxidative phosphorylation were observed in developed mass with advanced weeks. In addition, gene profile in ocular melanoma cell was quite different from another 2 cells, showing significant higher expression of genes related to cell proliferation signaling pathway (PI3K), pathways in cancer, gap and tight junction, and lower expression of genes related to cell proliferation signaling pathway, melanogenesis, and melanoma.

Report

(2 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (7 results)

All 2014 2013

All Presentation (5 results) Book (2 results)

  • [Presentation] 犬の顆粒細胞腫瘍の株化と株化細胞の特性2013

    • Author(s)
      山下傑夫、鈴木聡、岡野久美子、二瓶和美、田村俊介、内田和幸、小川博之
    • Organizer
      第156回日本獣医学会学術集会
    • Related Report
      2013 Final Research Report
  • [Presentation] ここまで使えるフローサイトメトリー2013

    • Author(s)
      盆子原誠
    • Organizer
      獣医臨床病理学会2013年大会
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 分子標的薬による肥満細胞腫の治療2013

    • Organizer
      獣医臨床フォーラム
    • Related Report
      2013 Final Research Report
  • [Presentation] 犬の顆粒細胞腫瘍の株化と株化細胞の特性2013

    • Author(s)
      山下傑夫
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 分子標的薬による肥満細胞腫の治療2013

    • Author(s)
      盆子原誠
    • Organizer
      獣医臨床フォーラム
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Book] イマチニブによる肥満細胞腫の治療, Veterinary Oncology2014

    • Publisher
      インターズー
    • Related Report
      2013 Final Research Report
  • [Book] Veterinary Oncology2014

    • Author(s)
      盆子原誠
    • Publisher
      インターズー
    • Related Report
      2013 Annual Research Report

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Published: 2014-07-25   Modified: 2016-11-25  

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