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The "structure" and "function" of mammary gland in stress pregnancy

Research Project

Project/Area Number 25660248
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Integrative animal science
Research InstitutionUniversity of Tsukuba

Principal Investigator

FUKAMIZU Akiyoshi  筑波大学, 生命環境系, 教授 (60199172)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords高血圧妊娠 / 乳腺 / レニン-アンジオテンシン系 / 授乳 / アンジオテンシンII受容体 / 妊娠 / レニン・アンジオテンシン系 / トランスジェニックマウス / ストレス妊娠 / 妊娠高血圧 / 病態モデルマウス / 乳腺発達 / アンジオテンシンII
Outline of Final Research Achievements

Angiotensin II (AngII) has critical roles in regulation of blood pressure. We previously generated pregnancy-associated hypertensive (PAH) mice by mating female human angiotensinogen transgenic mice with male human renin transgenic mice. A recent study demonstrated that angiotensin II type I receptor (AT1) is expressed in mammary epithelial cells, however, the role of AngII-AT1 signaling in the development of mammary gland during pregnancy remains unclear. In this study, we analyzed the mammary gland of PAH mice. PAH mice exhibited precocious lobuloalveolar development and increased milk protein and lipid production, indicating that mammary gland development was accelerated in PAH mice. Furthermore, AT1 blocker treatment suppressed acceleration of mammary gland development in PAH mice, while antihypertensive drug hydralazine treatment did not. These data suggest that AngII-AT1 signaling accelerates mammary gland development during pregnancy through hypertension-independent mechanism.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (14 results) (of which Invited: 2 results)

  • [Journal Article] A mouse renin distal enhancer is essential for blood pressure homeostasis in BAC-rescued renin-null mutant mice.2014

    • Author(s)
      Tanimoto K, Kanafusa S, Ushiki A, Matsuzaki H, Ishida J, Sugiyama F, Fukamizu A
    • Journal Title

      J. Recept. Signal Transduct.

      Volume: 34 Issue: 5 Pages: 401-409

    • DOI

      10.3109/10799893.2014.908917

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 妊娠高血圧マウスの乳腺発達に関する解析2015

    • Author(s)
      Baasanjav Altansarnai、村田知弥、石田純治、深水昭吉
    • Organizer
      第19回 アンジオテンシンカンファレンス
    • Place of Presentation
      都市センターホテル 東京都、千代田区
    • Year and Date
      2015-02-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] エピゲノムによる生体機能調節2014

    • Author(s)
      深水昭吉
    • Organizer
      第18回 日本心血管内分泌代謝学会
    • Place of Presentation
      横浜市開港記念会館 神奈川県、横浜市
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 妊娠高血圧モデルマウスにおいて増加するアミノプロダクトの同定2014

    • Author(s)
      加香孝一郎,中村あゆみ,川崎祥平,永島裕介,石田純治,深水昭吉
    • Organizer
      第18回 日本心血管内分泌代謝学会
    • Place of Presentation
      横浜市開港記念会館 神奈川県、横浜市
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 妊娠高血圧マウスへの複数の降圧剤投与による病態改善効果の検討2014

    • Author(s)
      石丸友博、石田純治、橋本美涼、Baasanjav Altansarnai、Xu Haojun、水上早瀬、権哲源、杉山文博、八神健一、深水昭吉
    • Organizer
      第18回 日本心血管内分泌代謝学会
    • Place of Presentation
      横浜市開港記念会館 神奈川県、横浜市
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 妊娠高血圧マウスの乳腺発達に関する解析2014

    • Author(s)
      Altansarnai Baasanjav、村田知弥、石田純治、深水昭吉
    • Organizer
      第35回日本妊娠高血圧学会
    • Place of Presentation
      新宿 京王プラザホテル 東京都、新宿区
    • Year and Date
      2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] EFFECT OF LACTATION ON POSTPARTUM CARDIAC FUNCTION OF PREGNANCY-ASSOCIATED HYPERTENSIVE MICE2014

    • Author(s)
      Junji Ishida, Kazuya Murata, Chiaki Saito, Juri Hamada, Fumihiro Sugiyama, Ken-ichi Yagami, and Akiyoshi Fukamizu
    • Organizer
      46th International Congress on Pathophysiology of Pregnancy
    • Place of Presentation
      新宿 京王プラザホテル 東京都、新宿区
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 妊娠高血圧マウスに対する複数の降圧剤投与による病態改善効果2014

    • Author(s)
      石丸友博、石田純治、中村匠子、橋本美涼、松倉頼、Baasanjav Altansarnai、徐昊珺、水上早瀬、権哲源、杉山文博、八神健一、深水昭吉
    • Organizer
      第5回 Molecular cardiovascular conference II
    • Place of Presentation
      神戸ベイシェラトンホテル 兵庫県、神戸市
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ameliorative effect of L-type calcium channel blocker on the pathological conditions in mice with pregnancy-associated hypertension2014

    • Author(s)
      Haojun Xu, Junji Ishida, Tomohiro Ishimaru, Altansarnai Baasanjav, Misuzu Hashimoto, Kazuyuki Noguchi, and Akiyoshi Fukamizu
    • Organizer
      第5回 Molecular cardiovascular conference II
    • Place of Presentation
      神戸ベイシェラトンホテル 兵庫県、神戸市
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 妊娠高血圧症候群病態に関与するアミノプロダクトの探索と同定2014

    • Author(s)
      加香孝一郎、永島裕介、石田純治、土屋敬広、嶋田崇史、深水昭吉
    • Organizer
      第9回 日本ケミカルバイオロジー学会
    • Place of Presentation
      大阪大学 大阪府、豊中市
    • Year and Date
      2014-06-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Combinatorial treatment with antihypertensive drugs prevents HELLP syndrome exacerbated by endothelial dysfunction in pregnant hypertensive mice.2014

    • Author(s)
      Junji Ishida, Tomohiro Ishimaru, Tanomu Matsukura, Shoko Nakamura, Haojun Xu, Altansarnai Baasanjav, Misuzu Hashimoto, Kazuya Murata, Katsumasa Nagano, Fumihiro Sugiyama, Ken-ichi Yagami, and Akiyoshi Fukamizu
    • Organizer
      International Vascular Biology Meeting 2014
    • Place of Presentation
      みやこメッセ 京都府、京都市
    • Year and Date
      2014-04-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Vascular endothelial dysfunction in mice with pregnancy-associated hypertension2014

    • Author(s)
      Tomohiro Ishimaru, Junji Ishida, Tanomu Matsukura, Katsumasa Nagano, Fumihiro Sugiyama, Ken-ichi Yagami, and Akiyoshi Fukamizu
    • Organizer
      International Vascular Biology Meeting 2014
    • Place of Presentation
      みやこメッセ 京都府、京都市
    • Year and Date
      2014-04-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Lactation causes cardiac contractile dysfunction in mice with pregnancy-associated hypertension2014

    • Author(s)
      村田知弥、齊藤千明、石田純治、濱田樹理、杉山文博、 八神健一、深水昭吉
    • Organizer
      第51回 日本臨床分子医学会
    • Place of Presentation
      東京国際フォーラム 東京都、千代田区
    • Year and Date
      2014-04-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 妊娠高血圧マウスの病態発症・進展に対するAT1シグナル阻害効果の検討2014

    • Author(s)
      石丸友博、石田純治、中村匠子、橋本美涼、松倉頼、中村あゆみ、Baasanjav Altansarnai、國田智、杉山文博、八神健一、深水昭吉
    • Organizer
      第51回 日本臨床分子医学会
    • Place of Presentation
      東京国際フォーラム 東京都、千代田区
    • Year and Date
      2014-04-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 妊娠高血圧と酸化ストレス  産前産後の基礎研究

    • Author(s)
      深水 昭吉
    • Organizer
      腎と妊娠研究会
    • Place of Presentation
      つくば国際会議場 茨城県
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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