GnRH signals in female mice induce male sexual behaviors via vomeronasal organs of males
| Project/Area Number |
25660251
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OHATA Motoko 北里大学, 獣医学部, 助教 (60453510)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 繁殖行動 / GnRH / 性フェロモン / エストロジェン / 獣医学 / メタスチン / キスペプチン / 生理学 / 中枢 |
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| Outline of Final Research Achievements |
When GnRH mutant (hpg) female mice were treated with estrogen and intra cerebrum GnRH, they were significantly chased by normal male mice. These changes were not observed in vomeonasal organ-removed male mice. There were several specific peaks in the urea of the estrogen and GnRH treated hpg mice. These findings suggest that female cerebral GnRH stimulates male sexual behaviors via the male vomeonasal organ and it is mediated by some kind of chemical in mice.
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Report
(4 results)
Research Products
(48 results)
