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Research on preparation of chiral material utilizing chiral crystallization and related phenomenon

Research Project

Project/Area Number 25670006
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Chemical pharmacy
Research InstitutionToho University

Principal Investigator

AZUMAYA Isao  東邦大学, 薬学部, 教授 (50276755)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsキラリティー / 結晶構造 / 分子間相互作用 / 立体化学 / 不斉結晶化 / 結晶成長 / キラルライブニング / 自然分晶 / 結晶多形 / 対称性の破れ / キラルライプニング
Outline of Final Research Achievements

Chiral crystallization is the phenomenon of obtaining optically active crystals from a solution of optically inactive compounds. In this research, we synthesized aromatic sulfonamides having various substituents on their aromatic rings and searched for compounds which show chiral crystallization using a simple screening method for crystallization conditions. For aromatic sulfonamides having indole moiety on amide nitrogen, 11 out of 47 compounds showed chiral crystallization. The ratio was very much higher than that of general achiral compounds or other aromatic sulfonamides we previously examined. A detailed investigation on the crystal structures of these aromatic sulfonamides suggested that a phenomenon of chiral crystallization is closely related to intermolecular interactions and their shape of molecule. The results of this research will contribute to elucidation of origin of chirality during crystallizations.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014 Other

All Presentation (5 results)

  • [Presentation] Helical Structure of Molecular Array Through Hydrogen Bonding Observed in Aromatic Sulfonamides and Optical Activity of the Crystals2016

    • Author(s)
      東屋功、吉川晶子、桝飛雄真、片桐幸輔、氷川英正
    • Organizer
      日本化学会第96春季年会2016
    • Place of Presentation
      同志社大学京田辺キャンパス(京都府京田辺市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] ハロゲン基を有する芳香族スルホンアミドの結晶構造に見られる特徴的な分子間相互作用2015

    • Author(s)
      吉川晶子、中司翔子、福島美岬、片桐幸輔、桝飛雄真、氷川英正、東屋功
    • Organizer
      第24回有機結晶シンポジウム
    • Place of Presentation
      広島大学霞キャンパス広仁会館(広島県広島市)
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] インドール骨格を含む芳香族スルホンアミドの結晶多形2014

    • Author(s)
      前埜 伊沙恵、片桐 幸輔・吉川 晶子・野澤 茉莉子・桝 飛雄真・氷川 英正・東屋 功
    • Organizer
      第23回有機結晶シンポジウム
    • Place of Presentation
      東邦大学習志野キャンパス(千葉県船橋市)
    • Year and Date
      2014-09-15
    • Related Report
      2014 Research-status Report
  • [Presentation] インドール骨格を含む芳香族スルホンアミド誘導体の不斉結晶化2014

    • Author(s)
      前埜 伊沙恵,片桐 幸輔,氷川 英正,吉川 晶子,東屋 功
    • Organizer
      シンポジウム モレキュラー・キラリティー
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2014-06-07
    • Related Report
      2014 Research-status Report
  • [Presentation] インドールを含む芳香族スルホンアミドの 結晶構造中に見られる特徴的な分子間相互作用

    • Author(s)
      前埜伊沙恵, 片桐 幸輔, 氷川 英正, 鈴木 英治, 東屋 功
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市総合体育館(熊本県熊本市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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