| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Chiral crystallization is the phenomenon of obtaining optically active crystals from a solution of optically inactive compounds. In this research, we synthesized aromatic sulfonamides having various substituents on their aromatic rings and searched for compounds which show chiral crystallization using a simple screening method for crystallization conditions. For aromatic sulfonamides having indole moiety on amide nitrogen, 11 out of 47 compounds showed chiral crystallization. The ratio was very much higher than that of general achiral compounds or other aromatic sulfonamides we previously examined. A detailed investigation on the crystal structures of these aromatic sulfonamides suggested that a phenomenon of chiral crystallization is closely related to intermolecular interactions and their shape of molecule. The results of this research will contribute to elucidation of origin of chirality during crystallizations.
|
