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Development of a separation method of innate protein using nanostructure

Research Project

Project/Area Number 25670009
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Physical pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

Kato Masaru  東京大学, 薬学研究科(研究院), 准教授 (30332943)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsナノマテリアル / 分離科学 / タンパク質 / ナノ粒子 / HPLC / 電気泳動 / 中空キャピラリー / モノリスカラム / 流体効果 / ナノ構造 / 電気二重層 / 流体力学
Outline of Final Research Achievements

Because property of nanomaterial, such as protein, nanoparticle, and nanotube, changes by small structure difference of nanomartial, we developed a method for separation of nanomaterials in this study. We succeeded in the separation of nanomaterials based on their size and surface.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (20 results)

All 2016 2015 2014 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 5 results,  Open Access: 3 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] Effect of nanoparticle surface on the HPLC elution profile of liposomal nanoparticles2016

    • Author(s)
      N. Ito, E. Yamamoto, T. Santa, T. Funatsu, M. Kato
    • Journal Title

      Pharm. Res.

      Volume: 印刷中 Issue: 6 Pages: 1440-1446

    • DOI

      10.1007/s11095-016-1886-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Comparison of the migration behavior of nanoparticles based on polyethylene glycol and silica using micellar electrokinetic chromatography2015

    • Author(s)
      M. Kato, M. Sasaki, Y. Ueyama, A. Koga, A. Sano, T. Higashi, T. Sanata
    • Journal Title

      Journal of Separation Sciences

      Volume: 38 Issue: 3 Pages: 468-474

    • DOI

      10.1002/jssc.201401086

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Rapid evaluation of the quantity of drugs encapsulated within nanoparticles by high-performance liquid chromatography in a monolithic silica column.2015

    • Author(s)
      Itoh Naoki, Santa Tomofumi, Kato Masaru
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: 407 Issue: 21 Pages: 6429-6434

    • DOI

      10.1007/s00216-015-8805-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid and mild purification method for nanoparticles from a dispersed solution using a monolithic silica disk.2015

    • Author(s)
      Itoh Naoki, Santa Tomofumi, Kato Masaru
    • Journal Title

      Journal of Chromatography A

      Volume: 1404 Pages: 141-145

    • DOI

      10.1016/j.chroma.2015.05.047

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elution of Two Separated Peaks after Injection of a Small Sample Volume Using an Autosampler2014

    • Author(s)
      L. Ren, K. Ishihara, M. Kato
    • Journal Title

      CHROMATOGRAPHY

      Volume: 35 Issue: 1 Pages: 59-62

    • DOI

      10.15583/jpchrom.2014.004

    • NAID

      130004684358

    • ISSN
      1342-8284, 1348-3315
    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Separation of cationic analytes by nonionic micellar electrokinetic chromatography using polyoxyethylene lauryl ether surfactants with different polyoxyethylene length2014

    • Author(s)
      J. P. Quirino, M. Kato
    • Journal Title

      Journal of Separation Sciences

      Volume: 37 Issue: 18 Pages: 2613-2617

    • DOI

      10.1002/jssc.201400500

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Simultaneous analysis of nanoparticles and small molecules by high-performance liquid chromatography using a silica monolithic column2014

    • Author(s)
      N. Itoh, A. Sano, T. Santa, M. Kato
    • Journal Title

      Analyst

      Volume: 139 Issue: 18 Pages: 4453-4457

    • DOI

      10.1039/c4an00819g

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] ナノマテリアルの分離分析法の開発2016

    • Author(s)
      加藤 大
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      パシフィッコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of nanoparticles and their analytical method for medical application2016

    • Author(s)
      Masaru Kato
    • Organizer
      BK21Plus Symposium for Nanobio Materials and Advanced Analytical Techniques
    • Place of Presentation
      昌原大学(韓国)
    • Year and Date
      2016-01-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] モノリス型カラムによる生体液中のDOXIL分析法の開発2015

    • Author(s)
      伊藤 直樹, 三田 智文, 船津 高志, 加藤 大
    • Organizer
      第26回クロマトグラフィー科学会議
    • Place of Presentation
      九州大学(福岡県福岡市東区)
    • Year and Date
      2015-11-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] モノリス型カラムによるナノメディシンの分離2015

    • Author(s)
      加藤 大
    • Organizer
      日本分析化学会第64年会
    • Place of Presentation
      九州大学(福岡県福岡市西区)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] モノリス型カラムを用いた生体試料中のナノ医薬品分離分析法の開発2015

    • Author(s)
      伊藤 直樹、三田 智文、船津 高志、加藤 大
    • Organizer
      日本分析化学会第64年会
    • Place of Presentation
      九州大学(福岡県福岡市西区)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] モノリス型カラムによるナノメディシンの分離2015

    • Author(s)
      伊藤直樹, 三田智文, 船津高志, 加藤 大
    • Organizer
      第22回クロマトグラフィーシンポジウム
    • Place of Presentation
      近畿大学(大阪府東大阪市)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 長い中空のキャピラリーカラムによる高理論段数での低分子化合物の分離2015

    • Author(s)
      任 麗英,石原一彦,加藤 大
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2015-03-26
    • Related Report
      2014 Research-status Report
  • [Presentation] モノリス構造を持つスピンカラムによるナノ粒子製剤の精製法の開発2015

    • Author(s)
      伊藤直樹,三田智文,加藤 大
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大(兵庫県神戸市)
    • Year and Date
      2015-03-26
    • Related Report
      2014 Research-status Report
  • [Presentation] ナノメディスンの材料がモノリス型カラムの分離に与える影響の検討2014

    • Author(s)
      伊藤直樹,三田智文,加藤 大
    • Organizer
      第25回クロマトグラフィー科学会議
    • Place of Presentation
      京都大学(京都府京都市)
    • Year and Date
      2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] オートサンプラーによる微小注入した時に二つのピークとして溶出の現象2014

    • Author(s)
      任 麗英、金野智浩、石原一彦、加藤 大
    • Organizer
      第19回LCテクノプラザ
    • Place of Presentation
      横浜情報文化センター(神奈川)
    • Related Report
      2013 Research-status Report
  • [Presentation] HPLCとCEを用いたナノメディソンの分析法を開発2014

    • Author(s)
      佐々 木稔、伊藤直樹、三田智文、加藤 大
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市総合体育館(熊本)
    • Related Report
      2013 Research-status Report
  • [Remarks] 研究室のホームページ

    • URL

      http://park.itc.u-tokyo.ac.jp/CNBI/kato/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 研究室のHP

    • URL

      http://park.itc.u-tokyo.ac.jp/CNBI/kato/index.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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