| Project/Area Number |
25670016
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | Setsunan University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Kohsaku 物質材料研究機構, 生体機能材料ユニット, 主幹研究員 (00455271)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 吸収促進 / バイオ医薬 / オリゴアルギニン / オリゴアルギニン固定化高分子 / エレクトロスプレー / 腸溶性 |
|---|
| Outline of Final Research Achievements |
There are a couple of problems that should be solved to develop oral formulations of biological medicines: safety of absorption enhancers and a reduction of efficacy of the enhancers through dilution in the gastrointestinal tract. We designed enteric-coated particles containing drugs and absorption enhancers. Electrospray deposition was applied for particle preparation. When both a drug and an absorption enhancer were organic compounds with low molecular weights, absorption-enhancing functions was boosted through their co-encapsulation. This was presumably because the drug was always accompanied by the enhancer during the gastrointestinal transit. Oral absorption of insulin was enhanced when it was co-administered with oligoarginine-linked polymers in a solution. When the dosage form was substituted with enteric-coated particles, insulin absorption was considerably reduced. This probably resulted from interactions between formulated substances.
|
