Drug discovery of innovative small molecules with inhibition of RAGE-GAG interaction
| Project/Area Number |
25670018
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
KAZUYUKI Sugahara 北海道大学, 先端生命科学研究科(研究院), 名誉教授 (60154449)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUMOTO Shuji 名城大学, 薬学部, 助教 (40443973)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | コンドロイチン硫酸 / RAGE / プロテオグリカン / 癌 / 糖鎖創薬 / 低分子化合物 / 転移 / アルツハイマー病 / 老化 / ヘパラン硫酸 / 糖尿病 / オリゴ糖 |
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| Outline of Final Research Achievements |
Previously, we demonstrated that pulmonary metastasis is initiated by interaction of CS chain on tumor cells with Receptor for Advanced Glycation End-products (RAGE) on lung. The aim of this study was to develop the seeds of new drugs, oligosaccharides, and small molecular compounds. It was established the preparation of oligosaccharides by the hydrolysis of CS-E with a subcritical water microreaction system, and the screening methodology for effective oligosaccharides by inhibition of the interaction of CS-E with RAGE. These observations will provide the seeds of new anti-cancer drug.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor.2015
Author(s)
Marina Koutsioumpa, Evangelia Poimenidi, Evangelia Pantazaka, Christina Theodoropoulou, Angeliki Skoura, Vasileios Megalooikonomou, Nelly Kieffer, Jose Courty, Shuji Mizumoto, Kazuyuki Sugahara, and Evangelia Papadimitriou.
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Journal Title
Molecular Cancer
Volume: 14
Issue: 1
Pages: 19-19
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia is caused by a novel mutation in B3GAT3.2015
Author(s)
Birgit S. Budde, Shuji Mizumoto, Ryo Kogawa, Christian Becker, Janine Altmuller, Holger Thiele, Franz Ruschendorf, Mohammad R. Toliat, Gerrit Kaleschke, Johannes M. Hammerle, Wolffang Hohne, Kazuyuki Sugahara, Peter Nurnberg, Ingo Kennerknecht.
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Journal Title
Human Genetics
Volume: in press
Issue: 7
Pages: 691-704
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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