Function of simjang that enhances transdetermination of Drosophila imaginal discs

• Project/Area Number: 25670019
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Tohoku University
• Principal Investigator: KURATA Shoichiro 東北大学, 薬学研究科(研究院), 教授 (90221944)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 発生･分化 / 再生

Outline of Final Research Achievements

The function of gene, simjang, that enhances transdetermination of Drosophila imaginal discs was analyzed in this study. Simjang enhanced the eye to wing transdetermination through Mi-2/NuRD complex. Furthermore, Simjang was suggested to enhance the transdetermination by re-programing of developmental program.

Research Products

• [Journal Article] Ectopic Antenna Induction by Overexpression of <i>CG17836/Xrp1</i> Encoding an AT-Hook DNA Binding Motif Protein in <i>Drosophila</i> (2013)
  • Author(s): Noriko Tsurui-Nishimura, Thanh Quang Nguyen, Tomonori Katsuyama, Tatsurou Minami, Hirofumi Furuhashi, Yoshiteru Oshima, and Shoichiro Kurata
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 77 Issue: 2 Pages: 339-344
  • DOI: 10.1271/bbb.120756
  • NAID: 10031164738
  • ISSN: 0916-8451, 1347-6947
  • Peer Reviewed
• [Presentation] 器官形成に関わるWGEの核内構造体における機能を介した染色体構造制御機構の解明 (2014)
  • Author(s): 小澤奈央，古橋寛史，沼尾恵利子，倉田祥一朗
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] ショウジョウバエ器官改変系を用いたMi2/NuRD複合体の機能解析 (2014)
  • Author(s): 寺西達、Nguyen Thanh Quang、古橋寛史、倉田祥一朗
  • Organizer: 第13回次世代を担う若手ファーマ・バイオフォーラム2014
  • Place of Presentation: 富山
  • Year and Date: 2014-09-20 – 2014-09-21
• [Presentation] ショウジョウバエの器官改変を誘導する因子Winged Eyeによるエピジェネティック制御機構の解析 (2013)
  • Author(s): 増子恵太、沼尾恵利子、木村宏、古橋寛史、倉田祥一朗
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Remarks] 東北大学大学院薬学研究科生命機能解析学分野
  • URL: http://www.pharm.tohoku.ac.jp/~seimei/seimei_original.html
• [Remarks] 生命機能解析学分野
  • URL: http://www.pharm.tohoku.ac.jp/~seimei/seimei_original.html