Investigation of the immunological function of the NASH-inducing transplanted NKT, and drug discovery
Project/Area Number |
25670022
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
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Research Institution | University of Toyama |
Principal Investigator |
KOIZUMI Keiichi 富山大学, 和漢医薬学総合研究所, 准教授 (10334715)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ケモカイン / CXCL16 / NASH / NKT / 肥満 / 欠損マウス |
Outline of Final Research Achievements |
NASH (nonalcoholic steatohepatitis) is a serious disease, which goes to liver cirrhosis and liver cancer. However, NASH progression mechanism is still unknown. Recently, we interestingly found a NASH-inducing transplanted NKT into the recipient of NKT cell-deficient mice. The purpose of this study is following two; 1.Analysis of the immunological function of the NKT cells. 2.Development of the new drug against NASH. As a result of our investigation, initial condition of NASH was observed by taking of CDAA diet for 2-weeks in CXCL16-deficient mice. Furthermore, it was clear that IFN-γ and TNF-α produced from hepatic mononuclear cells by the NKT cells is a effector molecule for lipid accumulation in liver cells.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.2014
Author(s)
Kee JY, Ito A, Hojo S, Hashimoto I, Igarashi Y, Tsuneyama K, Tsukada K, Irimura T, Shibahara N, Takasaki I, Inujima A, Nakayama T, Yoshie O, Sakurai H, Saiki I, Koizumi K.
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Journal Title
BMC Cancer.
Volume: 14
Issue: 1
Pages: 949-949
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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