Identification of a molecule involved in tumor progression using a patient-derived xenograft model
| Project/Area Number |
25670025
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NONOMURA Iwao 大阪大学, 医学系研究科泌尿器科, 教授 (30263263)
UEMURA Motonao 大阪大学, 医学系研究科泌尿器科, 教授 (40631015)
FUJITA Kazutoshi 大阪大学, 医学系研究科泌尿器科, 教授 (50636181)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 淡明型腎細胞がん / 患者がん組織移植マウス / LOXL2 / 悪性化 / 幹細胞 / 腎癌 / 癌患者組織移植マウス / 癌幹細胞 / miRNA / 患者癌組織移植マウス / 増殖因子 |
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| Outline of Final Research Achievements |
Clear cell renal cell carcinoma (ccRCC) is the most popular subtype of renal cell carcinoma (RCC). Early-stage ccRCC is curable by clinical surgery, but approximately one-third of all patients present locally metastatic cancer at the time of diagnosis. Therefore, an understanding of the molecular mechanisms of ccRCC progression is crucial for the discovery of molecular-targeted therapies. In the present study, we have established patient-derived xenograft models of ccRCC. The tumors serially transplanted in mice pathohistologically showed high-grade phenotypes. On the other hand, we found LOX-like protein 2 (LOXL2) that is involved in the progression of ccRCC. Our findings suggest that LOXL2 is a potent regulator of integrin α5/β1 protein levels and functions in a tumor-promoting capacity in ccRCC.
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Report
(3 results)
Research Products
(7 results)
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[Presentation] 泌尿器科癌 PDX モデルマウスを用いた 癌悪性化メカニズムの解析2015
Author(s)
瀬 遼, 神宮司 健太郎, 江川 博, 川上 竜司, 塚田 陽平, 柏木 悠里, 小林 巧明, 北惠 郁緒里, 上田 裕子, 深田 宗一朗, 中田 渡, 藤田 和利, 植村 元秀, 野々村 祝夫, 辻川 和丈
Organizer
日本薬学会第135年会
Place of Presentation
デザイン・クリエイティブセンター神戸
Year and Date
2015-03-26 – 2015-03-28
Related Report
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