| Project/Area Number |
25670033
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
MINAMI Masabumi 北海道大学, 薬学研究科(研究院), 教授 (20243040)
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| Co-Investigator(Kenkyū-buntansha) |
ISO Yukina
MATSUBARA Akira
MINAMISHIMA Takuya
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経科学 / 移植・再生医療 / 薬学 / 血液脳関門 / 骨髄幹細胞 / リアルタイムイメージング |
|---|
| Outline of Final Research Achievements |
We carried out antibody array analysis to identify the proteins contained in mouse astrocyte-conditioned medium (ACM), and examined the effects of those proteins on the blood-brain barrier (BBB) function using a mouse in vitro BBB model. We found that leukemia inhibitory facto (LIF) was contained in ACM and significantly attenuated barrier function. Because LIF belongs to Interleukin (IL)-6 family, we examined the effect of other family members IL-6 and oncostatin M on BBB function. Oncostatin M, but not IL-6, significantly attenuated barrier function. Further study for the molecular mechanism of the effects of LIF and oncostatin M may lead to development of the method to control BBB function.
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