Neural stem cells have directivity characteristics in the cell fate decision.
| Project/Area Number |
25670037
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
KASAI Atsushi 大阪大学, 薬学研究科(研究院), 助教 (40454649)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | miRNA / 神経幹細胞 / セロトニン / noggin / 運命決定 / BMP |
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| Outline of Final Research Achievements |
Neural stem cells have pluripotency to differentiate into a variety of neural cells, such as neuron and glia cells. Here, we showed that noggin treatment to embryonic stem cells changed miRNA expression patterns in neural stem cells differentiated by diverse methods and increased serotonin neuronal differentiation. These findings suggest that pluripotency of neural stem cells may be already assigned the directional differentiation.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Identification of the role of BMP and TGF-β signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro.2015
Author(s)
Yamasaki A, Kasai A, Toi A, Kurita M, Kimoto S, Hayata-Takano A, Nakazawa T, Nagayasu K, Shintani N, Hashimoto R, Ito A, Meltzer HY, Ago Y, Waschek JA, Onaka Y, matsuda T, Baba A, Hashimoto H.
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Journal Title
Journal of Neurochemistry,
Volume: 132(4)
Issue: 4
Pages: 418-428
DOI
Related Report
Peer Reviewed / Open Access
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