| Project/Area Number |
25670038
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pharmacology in pharmacy
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KASAI ATSUSHI 大阪大学, 大学院薬学研究科, 助教 (40454649)
BABA AKEMICHI 兵庫医療大学, 学長 (70107100)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | ミトコンドリア / 脳・神経 / 細胞死 / 酸化ストレス / 細胞分化 / 発現制御 / 化合物スクリーニング / ノックアウトマウス / DYRK1A / 脳･神経 / ルシフェラーゼ / ミトコンドリア動態 / 神経細胞 / プロモーター / ライブイメージング系 |
|---|
| Outline of Final Research Achievements |
Recently, much attention has been gathered on the mitochondrial fusion and division machinery as a novel drug targets for neurodegenerative diseases. In this study, we performed functional analyses of the novel factor MIFI (mitochondrial fusion inhibitor) in the neuronal development and cell death. The obtained results suggested that MIFI functions in the neuronal cells possibly from early development, is associated with oxidative stress status, and shows stimulatory effects in the insult-induced cell death of neuroblastoma SH-SY5Y cells. In addition, this study developed essential research tools for the further functional analyses of MIFI, such as chemical compounds regulating MIFI expression and mice lacking MIFI.
|
