| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Dependence on voltage-dependent Ca channel (VDCC) is relatively low in skin artery comparing with other arteries. This may account for its tolerance on low temperature, since activity of VDCC is decrease in low temperature. In sciatic nerve-injured model rat, damage of sympathetic nerve is accompanied with decrease of Ca extrusion in planter artery, which results in increase of response to contractile stimuli. This suggests that weak stimuli are enough to induce sufficient contraction in injured site. According to this opinion, we administrated low dose of vasodilator which showed vasodilation with increase in pain threshold. In this study, we demonstrated that treatments which cause vasodilating response can be tools for treatment of pain.
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