Search for plant-origin natural products by epigenetics-modifying chemicals

Research Project

Project/Area Number	25670044
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Natural medicines
Research Institution	Tohoku University
Principal Investigator	OSHIMA Yoshiteru 東北大学, 薬学研究科(研究院), 教授 (00111302)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	植物 / 二次代謝物 / エピジェネティクス / 酵素阻害剤 / 天然物 / 未利用遺伝子 / エピジェネシス / 植物細胞
Outline of Final Research Achievements	Novel secondary metabolites produced by plant cell culture lead to expansion of diversity of the compound library consisted by natural products. This research tried to produce useful secondary metabolites of plant cell cultures using the chemicals such as HDAC inhibitors which induce epigenetic change of gene-expression in the cells. As a result, concurrent addition of metabolic inhibitor and HDAC inhibitor in cell cultures was effective to recover the ability of secondary metabolite production of the plant cells.