Development of a novel compound and a novel target protein for multi-drug resistant cancer

• Project/Area Number: 25670049
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Drug development chemistry
• Research Institution: Osaka University
• Principal Investigator: ARISAWA Mitsuhiro 大阪大学, 薬学研究科(研究院), 准教授 (40312962)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Tomonori 慶応義塾大学, 薬学部, 教授 (30251151)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 多剤耐性 / シクロオキシゲナーゼ / インドール / 多剤耐性がん細胞 / 含窒素複素環 / インドメタシン / ルテニウム / メタセシス / 環化異性化反応

Outline of Final Research Achievements

We designed and synthesized conformationally restricted analogues and regioisomers of the nonsteroidal anti-inflammatory drug indomethacin. Evaluation of the inhibitory effects of these compounds on COX, P-glycoprotein, and multidrug-resistance indicated that NSAIDS modulation of multidrug resistant P-glycoprotein and multidrug-resistant protein-1 is not associated with COX-1 and COX-2 inhibitory activities.

Research Products

• [Journal Article] Formation of self-assembled multi-layer stable palladium nanoparticles for ligand-free coupling reactions (2015)
  • Author(s): Mitsuhiro Arisawa, Mohammad Al-Amin, Tetsuo Honma, Yusuke Tamenori, Satoshi Arai, Naoyuki Hoshiya, Takatoshi Sato, Mami Yokoyama, Akira Ishii, Masaki Takeguchi, Tsuyoshi Miyazaki, Masashi Takeuchi, Tomohiro Maruko, Satoshi Shuto
  • Journal Title: RSC Adv. Volume: 5 Issue: 1 Pages: 676-683
  • DOI: 10.1039/c4ra11215f
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Nickel-Catalyzed Suzuki-Miyaura Coupling of a Tertiary Iodocyclopropane with Wide Boronic Acid Substrate Scope: Coupling Reaction Outcome Depends on Radical Species Stability (2015)
  • Author(s): Keisuke Yotsuji, Naoyuki Hoshiya, Takaaki Kobayashi, Hayato Fukuda, Hiroshi Abe, Mitsuhiro Arisawa and Satoshi Shuto
  • Journal Title: Adv. Synth. Catal. Volume: 357 Issue: 5 Pages: 1022-1028
  • DOI: 10.1002/adsc.201401000
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Double Carbonylation of Aryl Iodides with Amines under an Atmospheric Pressure of Carbon Monoxide Using Sulfur- Modified Au-Supported Palladium (2015)
  • Author(s): Nozomi Saito Takahisa Taniguchi, Naoyuki Hoshiya, Satoshi Shuto, Mitsuhiro Arisawa, Yoshihiro Sato
  • Journal Title: Green Chem. Volume: 17 Issue: 4 Pages: 2358-2361
  • DOI: 10.1039/c4gc02469a
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 芳香族エナミドメタセシス反応の開発：生物活性多置換インドール化合物の設計・合成・機能評価 (2015)
  • Author(s): 有澤光弘、西田篤司、周東智
  • Journal Title: 有機合成化学協会誌 Volume: 73 Pages: 254-265
  • NAID: 130005065812
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Safe Removal of the Allyl Protecting Groups of Allyl Esters using a Recyclable, Low-leaching and Ligand-free Palladium Nanoparticle Catalyst (2015)
  • Author(s): Koji Takagi, Hayato Fukuda, Satoshi Shuto, Akira Otaka, Mitsuhiro Arisawa
  • Journal Title: Adv. Synth. Catal. Volume: 357
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Palladium-Nanoparticle-Catalyzed Direct Ethynylation of Aliphatic Carboxylic Acid Derivatives via C(sp3)-H Bond Functionalization (2014)
  • Author(s): Mohammad Al-Amin, Mitsuhiro Arisawa, Satoshi Shuto, Yusuke Ano, Mamoru Tobisu, Naoto Chatani
  • Journal Title: Adv. Synth. Catal. Volume: 356 Issue: 7 Pages: 1631-1637
  • DOI: 10.1002/adsc.201301180
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ligandーfree Suzuki-Miyaura Coupling with Sulfur-modified Gold-supported Palladium in the Synthesis of a Conformationally-Restricted Cyclopropane Compound Library with Three-Dimensional Diversity (2014)
  • Author(s): Mitsuhiro ARISAWA
  • Journal Title: ACS Combi. Sci. Volume: 16 Issue: 5 Pages: 215-220
  • DOI: 10.1021/co4001138
  • Peer Reviewed / Open Access
• [Journal Article] Palladium-Nanoparticle-Catalyzed 1,7-Palladium Migration Involving C-H Activation, Followed by Intramolecular Amination: Regioselective Synthesis of N1-Arylbenzotriazoles and an Evaluation of Their Inhibitory Activity Towards Indoleamine 2,3-Dioxygenase (2014)
  • Author(s): Koji Takagi, Mohammad Al-Amin, Naoyuki Hoshiya, Johan Wouters, Hiroshi Sugimoto, Yoshitsugu Shiro, Hayato Fukuda, Satoshi Shuto, Mitsuhiro Arisawa
  • Journal Title: J. Org. Chem. Volume: 79 Issue: 13 Pages: 6366-6371
  • DOI: 10.1021/jo5009838
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development of a New Class of Proteasome Inhibitors with an Epoxyketone Warhead: Rational Hybridization of Non-peptidic Belactosin Derivatives and Peptide Epoxyketones (2014)
  • Author(s): Shuhei Kawamura, Yuka Unno, Akira Asai, Mitsuhiro Arisawa, Satoshi Shuto
  • Journal Title: Bioorg. Med. Chem. Volume: 22 Issue: 12 Pages: 3091-3095
  • DOI: 10.1016/j.bmc.2014.04.032
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor (2014)
  • Author(s): Takaaki Kobayashi, Akihiro Suemasa, Arisa Igawa, Soichiro Ide, Hayato Fukuda, Hiroshi Abe, Mitsuhiro Arisawa, Masabumi Minami, Satoshi Shuto
  • Journal Title: ACS Med. Chem. Lett. Volume: 5 Issue: 8 Pages: 889-893
  • DOI: 10.1021/ml500134k
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Effect of a Dietary Supplement Containing Raspberry Ketone on CYP3A Activity. (2014)
  • Author(s): Sekizuka M, Qi JW, Aomori T, Okada Y, Nakamura K, Araki T, Horiuchi R, Ohta S, Nakamura T, Yamamoto K
  • Journal Title: Pharmaceutica Analytica Acta Volume: 5 Issue: 06 Pages: 302-302
  • DOI: 10.4172/2153-2435.1000302
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of DDR2, BRAF, EGFR and KRAS mutations as therapeutic targets in non-adenocarcinoma lung cancer patients. (2014)
  • Author(s): Yashima H, Shimizu K, Araki T, Aomori T, Ohtaki Y, Nagashima T, Enokida Y, Atsumi J, Nakamura T, Takeyoshi I, Yamamoto K.
  • Journal Title: Mol Clin Oncol. Volume: 2 Pages: 714-718
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative evaluation of biliary elimination of gadoxetate, a magnetic resonance imaging contrast agent, via geometrical isomer-specific transporting system in rats (2014)
  • Author(s): Junji Ogawa, Azusa Yokota, Takuya Araki, Tohru Aomori, Tomonori Nakamura, Koujirou Yamamoto, Ichiro Koshiishi
  • Journal Title: Biopharmaceutics & Drug Disposition Volume: 35 Issue: 6 Pages: 362-371
  • DOI: 10.1002/bdd.1907
  • Peer Reviewed / Open Access
• [Journal Article] Determination of Intracellular Darunavir by Liquid Chromatography Coupled with Fluorescence Detection. (2014)
  • Author(s): Nagano D, Araki T, Nakamura T, Yamamoto K.
  • Journal Title: J Chromatogr Sci. Volume: 52 Issue: 9 Pages: 1021-1025
  • DOI: 10.1093/chromsci/bmt147
  • Peer Reviewed / Open Access
• [Journal Article] Rational hopping of a peptidic scaffold into non-peptidic scaffolds: structurally novel potent proteasome inhibitors derived from a natural product, belactosin A. (2014)
  • Author(s): S. Kawamura, Y. Unno, T. Hirokawa, A. Asai, M. Arisawa, S. Shuto
  • Journal Title: Chem. Commun Volume: 50 Issue: 19 Pages: 2445-2447
  • DOI: 10.1039/c3cc48818g
  • NAID: 120005525210
  • Peer Reviewed
• [Journal Article] Structurally novel highly potent proteasome inhibitors created by the dtructure-nased hybridization of non-peptidic belactosin derivatives and peptide boronates. (2014)
  • Author(s): S. Kawamura, Y. Unno, A. Asai, M. Arisawa, S. Shuto
  • Journal Title: J. Med. Chem Volume: 57 Issue: 6 Pages: 2726-2735
  • DOI: 10.1021/jm500045x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Case report: dose adjustment of warfarin using genetic information and plasma concentration monitoring. (2014)
  • Author(s): Aomori T, Fujita Y, Obayashi K, Sato H, Kiyotani K, Nakamura K, Nakamura T, Yamamoto K.
  • Journal Title: J Clin Pharm Ther Volume: 39 (3) Issue: 3 Pages: 319-321
  • DOI: 10.1111/jcpt.12135
  • Peer Reviewed / Open Access
• [Journal Article] Investigation of the Non-Covalent Binding Mode of Covalent Proteasome Inhibitors around the Transition State by Combined Use of Cyclopropylic Strain-Based Conformational Restriction and Computational Modeling (2013)
  • Author(s): Shuhei KAWAMURA
  • Journal Title: J. Med. Chem. Volume: 56 Issue: 14 Pages: 5829-5842
  • DOI: 10.1021/jm400542h
  • Peer Reviewed / Open Access
• [Journal Article] One-Pot Ring-Closing Metathesis/1, 3-Dipolar Cycloaddition through Assisted Tandem Ruthenium Catalysis: Synthesis of a Dye with Isoindolo[2, 1-a]quinoline Structure (2013)
  • Author(s): Mitsuhiro Arisawa, Yuki Fujii, Hiroshige Kato, Hayato Fukuda, Takashi Matsumoto, Mika Ito, Hiroshi Abe, Yoshihiro Ito, and Satoshi Shuto
  • Journal Title: Angewandte Chemie International Edition Volume: 51 Issue: 3 Pages: 1003-1007
  • DOI: 10.1002/anie.201206765
  • Peer Reviewed
• [Journal Article] Three-Dimensional Structural Diversity-Oriented Peptidomimetics Based on the Cyclopropylic Strain. (2013)
  • Author(s): Akira MIZUNO
  • Journal Title: Org. Lett. Volume: 15 Pages: 1686-1689
  • Peer Reviewed
• [Journal Article] Conformational Restriction Approach to BACE1 InhibitorsII:SAR Study of the Isocytosine Derivatives Fixed with a cis-Cyclopropane Ring. (2013)
  • Author(s): Shuji YONEZAWA
  • Journal Title: Bioorg.Med.Chem.Lett. Volume: 23 Issue: 10 Pages: 2912-2915
  • DOI: 10.1016/j.bmcl.2013.03.056
  • Peer Reviewed
• [Journal Article] Suzuki-Miyaura cross-coupling reactions using a low-leaching and highly recyclable gold-supported palladium material and two types of microwave equipments (2013)
  • Author(s): M. Al-Amin, M. Akimoto, T. Tameno, X. Ohoki, N. Takahashi, N. Hoshiya, S. Shuto, M. Arisawa
  • Journal Title: Green Chemistry Volume: 16 Issue: 5 Pages: 1142-1145
  • DOI: 10.1039/c3gc00063j
  • Peer Reviewed
• [Journal Article] Potent Proteasome Inhibitors Derived from the Unnatural Cis-Cyclopropane Isomer of Belactosin A: Synthesis, Biological Activity, and Mode of Action. (2013)
  • Author(s): Shuhei KAWAMURA
  • Journal Title: J. Med. Chem. Volume: 56 Issue: 9 Pages: 3689-3700
  • DOI: 10.1021/jm4002296
  • Peer Reviewed
• [Journal Article] Design Synthesis, and Validation of Peptidomimetics with Three-dimentional Structure Diversity (2013)
  • Author(s): Akira MIZUNO
  • Journal Title: Peptide Science Volume: 49 Pages: 9-10
  • Peer Reviewed
• [Journal Article] DJ-1 cooperates with PYCR1 in cell protection against oxidative stress (2013)
  • Author(s): Tatsuki YASUDA
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 436 Pages: 289-294
  • Peer Reviewed
• [Journal Article] Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger. (2013)
  • Author(s): Tsuzuki, T., Sakaguchi, N., Kudoh, T., Takano, S., Uehara, M., Murayama, T., Sakurai, T., Hashii, M., Higashida, H., Weber, K., Guse, A.H., Kameda, T., Hirokawa, T., Kumaki, Y., Potter, B.V., Fukuda, H., Arisawa, M., Shuto, S.
  • Journal Title: Angew. Chem. Int. Ed. Engl Volume: 52 Issue: 26 Pages: 6633-6637
  • DOI: 10.1002/anie.201302098
  • Peer Reviewed
• [Journal Article] Development of Second Generation Gold-Supported Palladium Material with Low-Leaching and Recyolable Characteristics in Aromatic Amination (2013)
  • Author(s): M. Al-Amin, S. Arai, N. Hashiya, T. Honma, Y. Tamenori, T. Sato, M. Yokoyama, A. Ishii, M. Takeuchi, T. Maruko, S. Shuto, M. Arisawa
  • Journal Title: Journal of Organic Chemistry Volume: 78 Issue: 15 Pages: 7575-7581
  • DOI: 10.1021/jo4011415
  • Peer Reviewed
• [Journal Article] Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: Identification of an efficient lead for potent inhibitors of GABA transports (2013)
  • Author(s): Kazuaki NAKADA
  • Journal Title: Bioorg. Med. Chem. Volume: 21 Pages: 4938-4950
  • Peer Reviewed
• [Journal Article] A fluorescence-based method for evaluating inositol 1,4,5-trisphosphate receptor ligands: Determination of subtype selectivity and partial agonist effects (2013)
  • Author(s): Akihiko TANIMURA
  • Journal Title: Journal of Biotechnology Volume: 167 Issue: 3 Pages: 248-254
  • DOI: 10.1016/j.jbiotec.2013.06.012
  • Peer Reviewed
• [Journal Article] Design and synthesis of the stabilized analogs of belactosin A with the unnatural cis-cyclopropane structure (2013)
  • Author(s): Shuhei KAWAMURA
  • Journal Title: Org. Biomol. Chem Volume: 11 Issue: 38 Pages: 6615-6622
  • DOI: 10.1039/c3ob41338a
  • Peer Reviewed
• [Journal Article] Conformational restriction approach to β-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations (2013)
  • Author(s): Shuji YONEZAWA
  • Journal Title: Bioorg. Med. Chem. Volume: 21 Pages: 6506-6522
  • Peer Reviewed
• [Journal Article] Palladium-Catalyzed Arylation of Cyclopropanes via Directing Group-Mediated C(sp3)&H Bond Activation To Construct Quaternary Carbon Centers: Synthesis of cis- and trans-1,1,2-Trisubstituted Chiral Cyclopropanes (2013)
  • Author(s): Naoyuki HOSHIYA
  • Journal Title: Org. Lett. Volume: 15 Issue: 17 Pages: 6203-6205
  • DOI: 10.1021/ja00772a052
  • Peer Reviewed
• [Journal Article] Risk of Falling and Hypnotic Drugs: Retrospective Study of Inpatients. (2013)
  • Author(s): Kyoko Obayashi, Takuya Araki, Katsunori Nakamura, Masahiko Kurabayashi, Yoshihisa Nojima, Katsuyuki Hara, Tomonori Nakamura*, Koujirou Yamamoto.
  • Journal Title: Drugs in R&D Volume: 13 Issue: 2 Pages: 159-164
  • DOI: 10.1007/s40268-013-0019-3
  • Peer Reviewed
• [Journal Article] Rational hopping of a peptidic scaffold into non-peptidic scaffolds: structurally novel potent proteasome inhibitors derived from a natural product, belactosin A
  • Author(s): Shuhei Kawamura, Yuka Unno, Takatsugu Hirokawa, Akira Asai, Mitsuhiro Arisawa and Satoshi Shuto
  • Journal Title: Chem. Commun. Volume: 50 Pages: 2445-2447
  • NAID: 120005525210
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Preparation of nonracemic bromomethylenecyclopropane and its use in Suzuki-Miyaura coupling; synthesis of the arylmethyl-cis-cyclopropane structure core.
  • Author(s): Makoto TANABE
  • Journal Title: J. Org. Chem Volume: 78 Pages: 11714-11720
  • Peer Reviewed
• [Presentation] ハイプシン結合RNAアプタマー取得を目的とするハイプシン誘導体の設計と合成 (2015)
  • Author(s): 阿部 敬介, 小黒 明広, 西村 和洋, 市川 哲也, 藤岡 弘道, 有澤 光弘
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学（神戸市）
  • Year and Date: 2015-03-28
• [Presentation] ERCC1とPOLR3A：大腸癌細胞におけるオキサリプラチン感受性予測バイオマーカー 物質としての可能性 (2015)
  • Author(s): 北爪 賀子, 鈴木 小夜, 小林 典子, 中島 綾, 青森 達, 中村智徳
  • Organizer: 日本薬学会135年会
  • Place of Presentation: デザイン・クリエイティブセンター神戸1F KIITO ホール（神戸）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] アザチオプリン代謝酵素遺伝子多型の関節リウマチ治療効果に対する影響 (2015)
  • Author(s): 坂本麻味, 中島 綾, 小林典子, 石岡江梨子, 金子祐子, 青森 達, 鈴木小夜, 竹内 勤, 中村 智徳
  • Organizer: 日本薬学会135年会
  • Place of Presentation: デザイン・クリエイティブセンター神戸1F KIITO ホール（神戸）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 和漢薬と西洋薬の併用の適正性に関する疫学的研究 (2015)
  • Author(s): 葛西良佳, 青森 達, 坡下真大, 鈴木小夜, 小林典子, 中島 綾, 荒木 拓也, 山本 康次郎, 中村 智徳
  • Organizer: 日本薬学会135年会
  • Place of Presentation: デザイン・クリエイティブセンター神戸1F KIITO ホール（神戸）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 硫黄修飾金担持型ニッケル触媒の開発とアルキンへの二酸化炭素固定化反応の利用 (2015)
  • Author(s): 谷口 敬寿, 齋藤 望, 星谷 尚亨, 周東 智, 本間 徹生, 藤岡 弘道, 有澤 光弘, 佐藤美洋
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学（神戸市）
  • Year and Date: 2015-03-26
• [Presentation] 硫黄修飾金担持型ニッケル触媒を用いたリガンドフリークロスカップリング反応の開発 (2015)
  • Author(s): 藤木 勝将, 星谷 尚亨, 谷口 敬寿, 周東 智, 藤岡 弘道, 斎藤 望, 佐藤 美洋, 有澤光弘
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学（神戸市）
  • Year and Date: 2015-03-26
• [Presentation] エインメタセシス/異性化/Diels-Alder ワンポット反応の開発 (2015)
  • Author(s): 山下 航平, 藤岡 弘道, 有澤 光弘
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学（神戸市）
  • Year and Date: 2015-03-26
• [Presentation] Pd および Ni 触媒によるシクロプロパン第三級炭素上への芳香環導入反応 ―効率的化学空間探索型創薬ライブラリーの構築を目指して― (2014)
  • Author(s): 星谷尚亨,四辻慶佑,小林嵩明,福田 隼,阿部 洋,有澤光弘,周東 智
  • Organizer: 第40回反応と合成の進歩シンポジウム
  • Place of Presentation: 東北大学萩ホール（仙台市）
  • Year and Date: 2014-11-11
• [Presentation] Pd ナノ粒子触媒 SAPd を用いたアリルエステルの脱アリル化反応の開発 (2014)
  • Author(s): 高木耕治,福田 隼,阿部 洋,周東 智,大高 章,有澤光弘
  • Organizer: 第40回反応と合成の進歩シンポジウム
  • Place of Presentation: 東北大学萩ホール（仙台市）
  • Year and Date: 2014-11-11
• [Presentation] Ligand-free Suzuki-Miyaura Coupling with Sulfur-modified Gold-supported Palladium in the Synthesis of a Conformationally-Restricted Cyclopropane Compound Library with Three-Dimensional Diversity (2014)
  • Author(s): "Mitsuhiro Arisawa, Takatoshi Sato, Naoyuki Hoshiya, Mohammad Al-Amin, Yuji Kogami and Satoshi Shuto"
  • Organizer: The 2nd International Conference on Organometallics and Catalysis
  • Place of Presentation: Todaiji Temple Cultural Center Nara, Japan
  • Year and Date: 2014-10-27
• [Presentation] 硫黄修飾ガラス担持型パラジウムの開発:リガンドフリーBuchwald-Hartwig 反応 (2014)
  • Author(s): XiaoMincen、星谷尚亨、周東 智、藤岡弘道、 有澤光弘
  • Organizer: 第64回 日本薬学会近畿支部総会・大会
  • Place of Presentation: 京都薬科大学（京都市）
  • Year and Date: 2014-10-11
• [Presentation] 有機金属触媒を用いた機能性分子の創製 (2014)
  • Author(s): 有澤光弘
  • Organizer: 名城大学特別講演会
  • Place of Presentation: 名城大学（名古屋市）
  • Year and Date: 2014-10-10
  • Invited
• [Presentation] Ring-closing metathesis (RCM)/1,3-dipolar cycloaddition for the synthesis of isoindolo[2,1-a]quinolone structure dye (2014)
  • Author(s): Mitsuhiro Arisawa
  • Organizer: ETH Zürich – Osaka University Joint-symposium
  • Place of Presentation: 大阪大学基礎工学部Σホール（豊中市）
  • Year and Date: 2014-10-09
  • Invited
• [Presentation] 硫黄修飾ガラス担持型パラジウムの開発:リガン ドフリーBuchwald-Hartwig 反応 (2014)
  • Author(s): 肖 玟岑・星谷 尚亨・周東 智・藤岡 弘 道・有澤 光弘
  • Organizer: 第61回有機金属化学討論会
  • Place of Presentation: 九州大学病院キャンパス 医学部 百年講堂（福岡市）
  • Year and Date: 2014-09-25
• [Presentation] Grubbs 触媒を用いたアレンーエンの分子内[2+2]環 化反応:アザビシクロ[3.1.1]ヘプタン骨格の合成 (2014)
  • Author(s): 米重 勇祐・名田 智美・周東 智・ 藤岡 弘道・有澤 光弘
  • Organizer: 第61回有機金属化学討論会
  • Place of Presentation: 九州大学病院キャンパス 医学部 百年講堂（福岡市）
  • Year and Date: 2014-09-24
• [Presentation] ルテニウムカルベン錯体を用いたワンポット反応の開発と新規多環性複素環骨格の構築 (2014)
  • Author(s): 藤居 由基 ・加藤 宏茂・福田 隼・阿部 洋 ・藤岡 弘道 ・周東 智 ・有澤 光弘
  • Organizer: 第 44 回 複素環化学討論会
  • Place of Presentation: 札幌市民ホール（札幌市）
  • Year and Date: 2014-09-11
• [Presentation] 硫黄修飾金に担持した有機合成用金属ナノ粒子触媒の開発 (2014)
  • Author(s): 有澤光弘
  • Organizer: 第11回Spring-8産業利用報告会
  • Place of Presentation: 姫路商工会議所（姫路市）
  • Year and Date: 2014-09-04
  • Invited
• [Presentation] 硫黄修飾金に担持したニッ ケルナノ粒子触媒の開発 (2014)
  • Author(s): 藤木勝将、星谷尚之、谷口敬寿、 藤岡弘道、周東智、齋藤望、佐藤美洋、有澤光弘
  • Organizer: 第３４回有機合成若手セミナー「明日の有機合成を担う人のために」
  • Place of Presentation: 大阪大学会館（豊中市）
  • Year and Date: 2014-08-05
• [Presentation] One-Pot Ring-Closing Metathesis (RCM)/1,3-Dipolar Cycloaddition by an Assisted Tandem Ruthenium Catalysis for the Synthesis of an Isoindolo[2,1-a]quinoline Structure Dye (2014)
  • Author(s): Mitsuhiro Arisawa, Yuki Fujii, Hiroshige Kato, Hayato Fukuda, Hiroshi Abe, Hiromichi Fujioka, Satoshi Shuto
  • Organizer: XXVI International Conference on Organometallic Chemistry (ICOMC 2014)
  • Place of Presentation: Royton Sapporo, Sapporo, Japan.
  • Year and Date: 2014-07-14
• [Presentation] レゾルビンE2の安定化を指向した構造活性相関研究 (2014)
  • Author(s): 高倉 夕季 福田 隼 石村 航平 田辺 真人 有澤 光弘 周東 智
  • Organizer: 日本薬学会北海道支部 第141回例会
  • Place of Presentation: 札幌コンベンションセンター（札幌市）
  • Year and Date: 2014-05-24
• [Presentation] レゾルビンE2のシクロプロパン環導入に夜安定等価体の創製 (2014)
  • Author(s): 高倉夕季
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学（熊本県）
• [Presentation] Pdナノパーティクルを用いたC(sp2)-H結合活性化反応によるベンゾトリアゾール骨格の構築 (2014)
  • Author(s): 高木耕治
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学（熊本県）
• [Presentation] SAPd触媒を用いたヨウ化アリールのダブルカルボニル化反応の開発 (2014)
  • Author(s): 谷口敬寿
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学（熊本県）
• [Presentation] GABAトランスポーターサブタイプ特異的な新規阻害剤候補化合物の薬理活性評価 (2014)
  • Author(s): 井川ありさ
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学（熊本県）
• [Presentation] 各種CYP3A4変異型分子に対するグレープフルーツ果汁抽出物およびその成分のMBI特性 (2014)
  • Author(s): 秋好健志
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学（熊本県）
• [Presentation] CYP3A4変異型分子種における testosterone 及び midazolam の代謝に対する競合阻害剤の阻害強度の比較 (2014)
  • Author(s): 小縣淳子
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学（熊本県）
• [Presentation] 慶應義塾大学薬学部における海外アドバンスト病院実習の教育効果の評価 (2014)
  • Author(s): 三井梨恵子
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学（熊本県）
• [Presentation] 事前学習における服薬指導実習改善に向けた薬学5年生のコミュニケーション能力に関する分析 (2014)
  • Author(s): 桑原亜記
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学（熊本県）
• [Presentation] 吃逆に対する薬物治療に関する論文調査研究 (2014)
  • Author(s): 松元美奈子
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学（熊本県）
• [Presentation] 薬局におけるアドヒアランス国情のための点眼薬指導の提案 (2014)
  • Author(s): 今井奈津美
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学（熊本県）
• [Presentation] 日本における先発医薬品とジェネリック医薬品の臨床的同等性に関する文献調査 (2014)
  • Author(s): 吉田彩
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学（熊本県）
• [Presentation] 疎水性相互作用に基づく機能性核酸の開発 (2013)
  • Author(s): 遠藤秀幸
  • Organizer: 日本薬学会北海道支部第140年会（北海道）
  • Place of Presentation: 札幌コンベンションセンター（北海道）
• [Presentation] On-pot Ring-Closing Metathesis (RCM)/1,3-dipolar cycloaddition) by an Assisted Tandem Ruthenium Catalysis for the Synteisis of an Isoindolo[2,1-n]quinoline Structure Dye (2013)
  • Author(s): Mitsuhiro ARISAWA
  • Organizer: International Symposium on Metathesis and Related Chemistry（奈良県）
  • Place of Presentation: Todaiji-temple LectureHall（奈良県）
• [Presentation] On-pot Ring-Closing Metathesis (RCM)/1,3-dipolar cycloaddition) by an Assisted Tandem Ruthenium Catalysis for the Synteisis of an Isoindolo[2,1-n]quinoline Structure Dye (2013)
  • Author(s): Mitsuhiro ARISAWA
  • Organizer: The 3rd International Symposium on Molecular Activation
  • Place of Presentation: Sheraton Steamboat Resort （米国）
  • Invited
• [Presentation] Transition Metal Nanosized Palladium Particle for Organic Reaction (2013)
  • Author(s): Naoyuki HOSHIYA
  • Organizer: The 3rd International Symposium on Molecular Activation
  • Place of Presentation: Sheraton Steamboat Resort （米国）
• [Presentation] On-pot Ring-Closing Metathesis (RCM)/1,3-dipolar cycloaddition) by an Assisted Tandem Ruthenium Catalysis for the Synteisis of an Isoindolo[2,1-n]quinoline Structure Dye (2013)
  • Author(s): Mitsuhiro ARISAWA
  • Organizer: 17th International Symposium on Organometallic Chemistry directed toward Organic Synthesis
  • Place of Presentation: Colorado State University（米国）
• [Presentation] Palladium(0)-catalyzed Regioselective Intermolecular Direct Arylation of Tertiary Carbon on Cyclopropane (2013)
  • Author(s): Naoyuki HOSHIYA
  • Organizer: 17th International Symposium on Organometallic Chemistry directed toward Organic Synthesis
  • Place of Presentation: Colorado State University（米国）
• [Presentation] Sulfur-modified Au-supported Pd Catalyzed Double Carbonylation Reaction under Ligan-Free Conditions (2013)
  • Author(s): Takahisa TANIGUCHI
  • Organizer: 17th International Symposium on Organometallic Chemistry directed toward Organic Synthesis
  • Place of Presentation: Colorado State University（米国）
• [Presentation] Development of Sulfur-modified Au-supported Palladiium and its Use in Medicinal Research (2013)
  • Author(s): Koji Takagi
  • Organizer: 16th International Synposium of Reactions between Homogeneous and Heterogeneous Ctalysis (ISHHC-16)
  • Place of Presentation: Hokkaido University（北海道）
• [Presentation] 硫黄修飾金に担持したパラジウム触媒によるリガンドフリーダブルカルボニル化反応 (2013)
  • Author(s): 谷口敬寿
  • Organizer: 第60回有機金属化学討論会
  • Place of Presentation: 学習院大学（東京都）
• [Presentation] 光学活性第３級ヨードシクロプロパンとニッケル触媒を用いた鈴木－宮浦カップリング反応の開発 (2013)
  • Author(s): 四辻慶佑
  • Organizer: 第43回複素環化学討論会
  • Place of Presentation: 長良川国際会議場（岐阜県）
• [Presentation] ペプチド性天然物ベラクトシンAをプロトタイプとする高活性ペプチド性プロテアソーム阻害剤の創製：Scaford Hoppingに基づく理論的分子設計と合成 (2013)
  • Author(s): 川村周平
  • Organizer: 第39回反応と合成の進歩シンポジウム
  • Place of Presentation: 九州大学医学部百年講堂（福岡県）
• [Presentation] Design and Synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multi-drug resistant protein without cox inhibitory activity. (2013)
  • Author(s): Mitsuhiro ARISAWA
  • Organizer: Asian Federation for Pharmaceutical Sciences
  • Place of Presentation: Ramada Plaza Jeju Hotel（韓国）
  • Invited
• [Presentation] インスリン治療中の患者指導における簡易型血糖認識トレーニングの試み (2013)
  • Author(s): 宇都木敏浩
  • Organizer: 第56回日本糖尿病学会年次学術総会
  • Place of Presentation: ホテル日航熊本（熊本県）
• [Presentation] 薬局実務実習におけるOTC薬実習の問題点とその改善のための提案 (2013)
  • Author(s): 剱田侑希
  • Organizer: 第23回日本医療薬学会年会
  • Place of Presentation: 仙台国際センター（宮城県）
• [Presentation] カップリング反応による芳香環直結型光学活性三置換シクロプロパンの合成
  • Author(s): 四辻慶佑
  • Organizer: ２５周年記念 札幌万有シンポジウム（北海道）
  • Place of Presentation: 北海道大学工学部オープンホール（北海道）
• [Remarks] 大阪大学大学院薬学研究科分子合成化学分野
  • URL: http://gosei.sakura.ne.jp/gosei/
• [Patent(Industrial Property Rights)] 金属触媒ナノ粒子含有複合体及びその利用 (2014)
  • Inventor(s): 有澤光弘、周東智、星谷尚亨、新井聡史
  • Industrial Property Rights Holder: 有澤光弘、周東智、星谷尚亨、新井聡史
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-03-28
  • Overseas