Development of in vitro model system to predict the renal secretion of drugs in human kidney
Project/Area Number |
25670074
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
|
Research Institution | Ritsumeikan University |
Principal Investigator |
|
Research Collaborator |
UESHIMA Satoshi 立命館大学, 薬学部, 助教
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 薬物動態学 / 薬学 / 腎排泄 / トランスポーター / 培養細胞 |
Outline of Final Research Achievements |
To develop in vitro experimental model systems to predict the renal secretion of drugs in human kidney, we treated the human kidney-derived cultured cells by various reagents to stimulate the expression of drug transporters. When HK-2 cells were treated with DNA methyltransferase inhibitor, the expression of OCT2 mRNA was significantly enhanced. It was demonstrated that the transport function of OCT2 was also enhanced. Development of in vitro experimental model systems to predict the renal secretion of drugs in human kidney will be useful for drug discovery and development.
|
Report
(4 results)
Research Products
(9 results)
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[Journal Article] Safety and efficacy of sustained release of basic fibroblast growth factor using gelatin hydrogel in patients with critical limb ischemia.2015
Author(s)
Kumagai M, Marui A, Tabata Y, Takeda T, Yamamoto M, Yonezawa A, Tanaka S, Yanagi S, Ito-Ihara T, Ikeda T, Murayama T, Teramukai S, Katsura T, Matsubara K, Kawakami K, Yokode M, Shimizu A, Sakata R.
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Journal Title
Heart and Vessels
Volume: 30
Issue: 5
Pages: 713-721
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The effect of ABCG2 genotype on the population pharmacokinetics of sunitinib in patients with renal cell carcinoma2014
Author(s)
Mizuno T, Fukudo M, Fukuda T, Terada T, Dong M, Kamba T, Yamasaki T, Ogawa O, Katsura T, Inui K, Vinks AA, Matsubara K.
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Journal Title
Ther Drug Monit
Volume: 36
Issue: 3
Pages: 310-316
DOI
Related Report
Peer Reviewed
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[Journal Article] Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins.2014
Author(s)
Kato K, Mori H, Kito T, Yokochi M, Ito S, Inoue K, Yonezawa A, Katsura T, Kumagai Y, Yuasa H, Moriyama Y, Inui K, Kusuhara H, Sugiyama Y.
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Journal Title
Pharmaceutical Research
Volume: 31
Issue: 1
Pages: 136-147
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Population pharmacokinetics/pharmacodynamics of erlotinib and pharmacogenomic analysis of plasma and cerebrospinal fluid drug concentrations in Japanese patients with non-small cell lung cancer.2013
Author(s)
Fukudo M, Ikemi Y, Togashi Y, Masago K, Kim YH, Mio T, Terada T, Teramukai S, Mishima M, Inui K, Katsura T.
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Journal Title
Clinical Pharmacokinetics
Volume: 52
Issue: 7
Pages: 593-609
DOI
Related Report
Peer Reviewed
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