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Approach to develop a dynamics control technology of nanomaterial for oral nano-vaccine carrier

Research Project

Project/Area Number 25670075
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionOsaka University

Principal Investigator

TSUTSUMI Yasuo  大阪大学, 薬学研究科(研究院), 教授 (50263306)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords経口ワクチン / 新興再興感染症
Outline of Final Research Achievements

In this study, by the foundation of our own linkage information between physical properties of nanomaterials and the information of dynamics, we attempted to analyze the kinetics of antigen-nanoparticles that are not given a hand though it is most important thing for development of vaccine. From this study, we tried to collect the fundamental information toward the establishment of Japanese originated nano-vaccine. In the future, accumulation of linkage information of various nanomaterials with their dynamics might result in development of nano-carrier that can transport the antigen from the mouth to the immunocompetent cells, and that can induce mucosal immunity effectively and safety.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 2 results)

  • [Journal Article] Intestinal absorption and biological effects of orally administered amorphous silica particles.2014

    • Author(s)
      Yoshida T., Yoshioka Y., Takahashi H., Misato K., Mori T., Hirai T., Nagano K., Abe Y., Mukai Y., Kamada H., Tsunoda S., Nabeshi H., Yoshikawa T., Higashisaka K., Tsutsumi Y.
    • Journal Title

      Nanoscale Res Lett.

      Volume: 9 Issue: 1 Pages: 532-532

    • DOI

      10.1186/1556-276x-9-532

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] ナノマテリアルの細胞内挙動の理解に向けた基礎的解析2014

    • Author(s)
      青山道彦, 吉岡靖雄, 新井由之, 石本里緒, 永井健治, 東阪和馬, 堤 康央
    • Organizer
      第30回日本DDS学会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-30 – 2014-07-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] ナノマテリアルのADMET研究の現状と創薬への展開2013

    • Author(s)
      堤 康央
    • Organizer
      創薬動態フォーラム2013
    • Place of Presentation
      石川
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ナノ安全科学研究の現状と今後~トキシコ・バイオマーカー探索から代替法開発を含めて~2013

    • Author(s)
      堤 康央
    • Organizer
      日本動物実験代替法学会第26回大会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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