Approach to develop a dynamics control technology of nanomaterial for oral nano-vaccine carrier
Project/Area Number |
25670075
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
|
Research Institution | Osaka University |
Principal Investigator |
TSUTSUMI Yasuo 大阪大学, 薬学研究科(研究院), 教授 (50263306)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 経口ワクチン / 新興再興感染症 |
Outline of Final Research Achievements |
In this study, by the foundation of our own linkage information between physical properties of nanomaterials and the information of dynamics, we attempted to analyze the kinetics of antigen-nanoparticles that are not given a hand though it is most important thing for development of vaccine. From this study, we tried to collect the fundamental information toward the establishment of Japanese originated nano-vaccine. In the future, accumulation of linkage information of various nanomaterials with their dynamics might result in development of nano-carrier that can transport the antigen from the mouth to the immunocompetent cells, and that can induce mucosal immunity effectively and safety.
|
Report
(3 results)
Research Products
(4 results)
-
[Journal Article] Intestinal absorption and biological effects of orally administered amorphous silica particles.2014
Author(s)
Yoshida T., Yoshioka Y., Takahashi H., Misato K., Mori T., Hirai T., Nagano K., Abe Y., Mukai Y., Kamada H., Tsunoda S., Nabeshi H., Yoshikawa T., Higashisaka K., Tsutsumi Y.
-
Journal Title
Nanoscale Res Lett.
Volume: 9
Issue: 1
Pages: 532-532
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-